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PD 146176

Cat. No. 2850 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective 15-lipoxygenase inhibitor
Chemical Name: 6,11-Dihydro[1]benzothiopyrano[4,3-b]indole
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PD 146176

PD 146176 is a specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC50 = 0.54 μM for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo.

Compound Libraries for PD 146176

PD 146176 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PD 146176

M. Wt 237.32
Formula C15H11NS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 4079-26-9
PubChem ID 297589
InChI Key ZGOOPZVQMLHPFM-UHFFFAOYSA-N
Smiles C12=CC=CC=C1C3=C(C(C=CC=C4)=C4SC3)N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PD 146176

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.73 100
ethanol 11.87 50

Preparing Stock Solutions for PD 146176

The following data is based on the product molecular weight 237.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.21 mL 21.07 mL 42.14 mL
5 mM 0.84 mL 4.21 mL 8.43 mL
10 mM 0.42 mL 2.11 mL 4.21 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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References for PD 146176

References are publications that support the biological activity of the product.

Sendobry et al (1997) Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br.J.Pharmacol. 120 1199 PMID: 9105693

Bocan et al (1998) A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit. Atherosclerosis 136 203 PMID: 9543090

Sordillo et al (2005) Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells. Prostaglandins Other Lipid Mediat. 76 19 PMID: 15967159

If you know of a relevant reference for PD 146176, please let us know.

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Keywords: PD 146176, PD 146176 supplier, Selective, 15-lipoxygenase, inhibitors, inhibits, Oxygenases, Oxidases, PD146176, 15-LOX, ferroptosis, Lipoxygenase, Ferroptosis, 2850, Tocris Bioscience

1 Citation for PD 146176

Citations are publications that use Tocris products. Selected citations for PD 146176 include:

Ruparel et al (2012) Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. Cancer Res 153 2031 PMID: 22633978

Do you know of a great paper that uses PD 146176 from Tocris? Please let us know.

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