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Submit Reviewα,β-Methyleneadenosine 5'-triphosphate trisodium salt
Description: Non-selective P2 agonist
Alternative Names: α,β-meATP
Chemical Name: α,β-Methyleneadenosine 5'-triphosphate trisodium salt
Purity: ≥98% (HPLC)
Biological Activity
α,β-Methyleneadenosine 5'-triphosphate trisodium salt is a P2-purinoceptor agonist. Also shown to inhibit adenylate cyclase (Ki = 0.5 mM).
Technical Data
| M. Wt | 571.15 |
| Formula | C11H15N5Na3O12P3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1343364-54-4 |
| PubChem ID | 90488813 |
| InChI Key | CBAGKCWFSRTVER-MTQUBGKESA-K |
| Smiles | O[C@@H]1[C@@H](COP(CP([O-])(OP([O-])(O)=O)=O)([O-])=O)O[C@@H](N3C2=NC=NC(N)=C2N=C3)[C@@H]1O.[Na+].[Na+].[Na+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 57.12 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 571.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.75 mL | 8.75 mL | 17.51 mL |
| 5 mM | 0.35 mL | 1.75 mL | 3.5 mL |
| 10 mM | 0.18 mL | 0.88 mL | 1.75 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Krug et al (1973) α,β-Methylene-adenosine 5'-triphosphate. J.Biol.Chem. 248 1203 PMID: 4686923
Burnstock and Kennedy (1985) Is there a basis for distinguishing two types of P2-purinoceptor? Gen.Pharmacol 16 433 PMID: 2996968
If you know of a relevant reference for α,β-Methyleneadenosine 5'-triphosphate trisodium salt, please let us know.
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Keywords: alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt, alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt supplier, P2, agonists, P2-purinoceptor, P2Y, Receptors, Purinergic, P2X, purinoceptors, α, β-Methyleneadenosines, alpha,beta-Methyleneadenosines, 5-triphosphate, trisodium, salt, a,b-Methyleneadenosine, a,b-meATP, 3209, Tocris Bioscience
2 Citations for α,β-Methyleneadenosine 5'-triphosphate trisodium salt
Citations are publications that use Tocris products. Selected citations for α,β-Methyleneadenosine 5'-triphosphate trisodium salt include:
Palygin et al (2018) Characterization of purinergic receptor expression in ARPKD cystic epithelia. Purinergic Signal 14 485 PMID: 30417216
Haanes and Edvinsson (2014) Expression and characterization of purinergic receptors in rat middle meningeal artery-potential role in migraine. PLoS One 9 e108782 PMID: 25265286
Do you know of a great paper that uses α,β-Methyleneadenosine 5'-triphosphate trisodium salt from Tocris? Please let us know.
Reviews for α,β-Methyleneadenosine 5'-triphosphate trisodium salt
Average Rating: 4 (Based on 1 Review.)
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Filter by:
P2 agonist.
By
Anonymous on 05/17/2018
Species: Human
P2X1 and P2X3 agonist, the product works as expected.
Literature in this Area
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P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.