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Description: Enkephalin-degrading and ACE inhibitor
Biological Activity for Spinorphin
Spinorphin is an endogenous peptide; inhibits enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase III, neprilysin) and angiotensin-converting enzyme. Displays antinociceptive effects in mice.
Technical Data for Spinorphin
| M. Wt | 877.05 |
| Formula | C45H64N8O10 |
| Sequence | LVVYPWT |
| Storage | Desiccate at -20°C |
| CAS Number | 137201-62-8 |
| PubChem ID | 3081832 |
| InChI Key | BXIFNVGZIMFBQB-DYDSHOKNSA-N |
| Smiles | [H]N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Spinorphin
References for Spinorphin
References are publications that support the biological activity of the product.
Honda et al (2001) Spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, potentiates Leu-enkephalin-induced anti-allodynic and antinociceptive effects in mice. Jpn.J.Pharmacol. 87 261 PMID: 11829145
Liang et al (2001) The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPR. J.Immunol. 167 6609 PMID: 11714831
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Keywords: Spinorphin, Spinorphin supplier, Potent, P2X3, antagonists, Enkephalin-degrading, ACE, inhibitors, inhibits, Receptors, Purinergic, purinoceptors, Angiotensin-Converting, Enzyme, Proteinases, Proteases, Other, 2931, Tocris Bioscience
Citations for Spinorphin
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Currently there are no citations for Spinorphin.
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