Home / Cell Biology / Regulated Cell Death / Apoptosis / Apoptosis Inducers / Streptozocin

Streptozocin

Cat. No. 1621 1 Review Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: DNA alkylator; antitumor and induces diabetes
Alternative Names: Streptozotocin
Chemical Name: 2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (1)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Streptozocin

Streptozocin is an antibiotic and antitumor agent. Alkylates DNA and induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic β-cells in vivo.

Technical Data for Streptozocin

M. Wt 265.22
Formula C8H15N3O7
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 18883-66-4
PubChem ID 2733335
InChI Key ZSJLQEPLLKMAKR-YDEIVXIUSA-N
Smiles O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(N(C)N=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Streptozocin

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.52 100
DMSO 26.52 100

Preparing Stock Solutions for Streptozocin

The following data is based on the product molecular weight 265.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.77 mL 18.85 mL 37.7 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
10 mM 0.38 mL 1.89 mL 3.77 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Streptozocin

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for Streptozocin

References are publications that support the biological activity of the product.

Bennett and Pegg (1981) Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 41 2786 PMID: 6454479

Weis (1982) Steptozotocin: A review of its pharmacology, efficacy and toxicity. Cancer Treat. Rep. 66 427 PMID: 6277485

If you know of a relevant reference for Streptozocin, please let us know.

View Related Products by Target

Keywords: Streptozocin, Streptozocin supplier, DNA, alkylators, antitumor, antitmour, induces, diabetes, Apoptosis, Inducers, antibiotics, chemotherapeutics, Streptozotocin, Antibiotics, 1621, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Streptozocin (streptozotocin), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Streptozocin

Citations are publications that use Tocris products.

Currently there are no citations for Streptozocin. Do you know of a great paper that uses Streptozocin from Tocris? Please let us know.

Reviews for Streptozocin

Average Rating: 5 (Based on 1 Review.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used Streptozocin?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Streptozocin used on GLUT2 positive neuroendocrine tumor cells.
By Anonymous on 02/18/2019
Species: Human
Cell Line/Tissue: GLUT2 positive neuroendocrine tumor cells

Streptozocin used on GLUT2 positive neuroendocrine tumor cells.Streptozocin was used to induce type 1 diabetes

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Streptozocin

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.