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Submit Review2-Methylthioadenosine diphosphate trisodium salt
Description: Potent agonist at P2Y1, P2Y12 and P2Y13
Alternative Names: 2-(Methylthio)adenosine 5'-diphosphate,2-Methylthio-ADP,MeSADP
Chemical Name: 2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt
Purity: ≥98% (HPLC)
Biological Activity
2-Methylthioadenosine diphosphate trisodium salt is a potent purinergic agonist displaying selectivity for P2Y1, P2Y12 and P2Y13 receptors (pEC50 = 8.29 and 9.05 for P2Y1 and P2Y12, EC50 = 19 nM for P2Y13). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro.
Technical Data
| M. Wt | 539.24 |
| Formula | C11H14N5Na3O10P2S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 475193-31-8 |
| PubChem ID | 52942441 |
| InChI Key | DYNGCIHMNWOBSU-MSQVLRTGSA-K |
| Smiles | O[C@@H]1[C@@H](COP(OP([O-])([O-])=O)([O-])=O)O[C@@H](N3C2=NC(SC)=NC(N)=C2N=C3)[C@@H]1O.[Na+].[Na+].[Na+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
Product Datasheets
References
References are publications that support the biological activity of the product.
Macfarlane et al (1983) 2-Methylthioadenosine[β-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J.Clin.Invest. 71 420 PMID: 6298277
Sak and Webb (2002) A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch.Biochem.Biophys. 397 131 PMID: 11747319
Zhang et al (2002) P2Y13: identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J.Pharmacol.Exp.Ther. 301 705 PMID: 11961076
If you know of a relevant reference for 2-Methylthioadenosine diphosphate trisodium salt, please let us know.
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Keywords: 2-Methylthioadenosine diphosphate trisodium salt, 2-Methylthioadenosine diphosphate trisodium salt supplier, Potent, agonists, P2Y1, P2Y12, P2Y13, Receptors, Purinergic, purinoceptors, p2yt, 2-methylthio-ADP, 2MeSADP, ME2SADP, 2-(Methylthio)adenosine, 5'-diphosphate, 2-Methylthio-ADP, MeSADP, P2Y, 1624, Tocris Bioscience
12 Citations for 2-Methylthioadenosine diphosphate trisodium salt
Citations are publications that use Tocris products. Selected citations for 2-Methylthioadenosine diphosphate trisodium salt include:
Manne et al (2018) PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway. J Thromb Haemost 16 1211 PMID: 29575487
Wang et al (2012) Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+. Nature 5 ra26 PMID: 22472648
Madry et al (2018) Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. Neuron 97 299 PMID: 29290552
Lu et al (2018) The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration. Front Pharmacol 9 242 PMID: 29725296
Hilt et al (2019) Platelet-derived β2M regulates monocyte inflammatory responses. JCI Insight 4 PMID: 30702442
Zhang et al (2014) Agonist-bound structure of the human P2Y12 receptor. Purinergic Signal 509 119 PMID: 24784220
Voss et al (2014) The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss. Br J Pharmacol 10 455 PMID: 24510452
Ilatovskaya et al (2013) Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol 305 C1050 PMID: 24048730
Zhang et al (2019) P2Y1 Purinergic Receptor Modulate Axon Initial Segment Initial Development. Front Cell Neurosci 13 152 PMID: 31068791
Modjeski et al (2016) Glutamate Receptor Interacting Protein 1 Mediates Platelet Adhesion and Thrombus Formation. PLoS One 11 e0160638 PMID: 27631377
Yamanaka et al (2012) A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. PLoS One 7 e45032 PMID: 23056190
Ohtani et al (2008) Evidence for the possible involvement of the P2Y(6) receptor in Ca (2+) mobilization and Ins secretion in mouse pancreatic islets. Purinergic Signal 4 365 PMID: 18784987
Do you know of a great paper that uses 2-Methylthioadenosine diphosphate trisodium salt from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.