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Submit ReviewHerbimycin A
Description: Src family kinase inhibitor. Also Hsp90 inhibitor
Chemical Name: (15R)-17-demethoxy-15-methoxy-11-O-methyl-geldanamycin
Purity: ≥95% (HPLC)
Biological Activity for Herbimycin A
Herbimycin A is an ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Exhibits antiangiogenic activity in endothelial cells in vitro. Also inhibits Hsp90 and impairs recovery from heat shock.
Technical Data for Herbimycin A
| M. Wt | 574.67 |
| Formula | C30H42N2O9 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 70563-58-5 |
| PubChem ID | 6436247 |
| InChI Key | MCAHMSDENAOJFZ-GDYSMBPZSA-N |
| Smiles | O=C1C=C([C@H](OC)[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Herbimycin A
References for Herbimycin A
References are publications that support the biological activity of the product.
Fukazawa et al (1994) Labeling of v-Src and BCR-ABL tyrosine kinases with [14C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism. FEBS Lett. 340 155 PMID: 8131836
McCollum et al (2004) Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity. Exp.Eye Res. 78 987 PMID: 15051479
Duncan (2005) Inhibition of Hsp90 function delays and impairs recovery from heat shock. FEBS J. 272 5244 PMID: 16218955
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Keywords: Herbimycin A, Herbimycin A supplier, Hsp90, inhibitors, inhibits, Src, family, kinase, Heat, Shock, Protein, 90, p60v-src, p210BCR-ABL, Kinases, HerbimycinA, antibiotics, Antiangiogenics, Antibiotics, 1629, Tocris Bioscience
Citations for Herbimycin A
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Currently there are no citations for Herbimycin A.
Reviews for Herbimycin A
Average Rating: 5 (Based on 1 Review.)
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We studied mechanisms of resistance to Herbimycin A.
By
Anonymous on 02/27/2019
Species: Human
We studied mechanisms of resistance to Herbimycin A (ansamycin antibiotics) in human breast cancer cell lines.
