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Description: Antioxidant and neuroprotective agent
Chemical Name: 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
Purity: ≥99% (HPLC)
Biological Activity for Idebenone
Idebenone is an antioxidant and neuroprotective agent. Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro and in vivo. Inhibits apoptosis of astrocytes via increased NGF production.
Technical Data for Idebenone
| M. Wt | 338.44 |
| Formula | C19H30O5 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 58186-27-9 |
| PubChem ID | 3686 |
| InChI Key | JGPMMRGNQUBGND-UHFFFAOYSA-N |
| Smiles | O=C(C(OC)=C1OC)C(CCCCCCCCCCO)=C(C)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Idebenone
References for Idebenone
References are publications that support the biological activity of the product.
Zs-Nagy (1990) Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone: a review. Arch.Gerontol.Geriatr. 11 177 PMID: 15374467
Civenni et al (1999) Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes. Eur.J.Pharmacol. 370 161 PMID: 10323265
Takuma et al (2000) CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production. Eur.J.Pharmacol. 406 333 PMID: 11040339
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Keywords: Idebenone, Idebenone supplier, Antioxidant, neuroprotective, agent, Antioxidants, Ferroptosis, 3002, Tocris Bioscience
1 Citation for Idebenone
Citations are publications that use Tocris products. Selected citations for Idebenone include:
Liu et al (2014) Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress. Antioxid Redox Signal 21 1571 PMID: 24328731
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