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Submit ReviewNSC 632839 hydrochloride
Description: Inhibitor of ubiquitin isopeptidase activity
Alternative Names: F6
Chemical Name: 3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for NSC 632839 hydrochloride
NSC 632839 hydrochloride is an inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 values are 15.65 and 16.23 μM in E1A and E1A/C9CN cells respectively).
Technical Data for NSC 632839 hydrochloride
| M. Wt | 339.86 |
| Formula | C21H21NO.HCl |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 157654-67-6 |
| PubChem ID | 5351362 |
| InChI Key | ZOKZLTXPTLIWOJ-BYCVLTJGSA-N |
| Smiles | O=C(/C(CNC3)=C/C2=CC=C(C)C=C2)/C3=C/C1=CC=C(C)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NSC 632839 hydrochloride
References for NSC 632839 hydrochloride
References are publications that support the biological activity of the product.
Aleo et al (2006) Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 66 9235 PMID: 16982768
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Keywords: NSC 632839 hydrochloride, NSC 632839 hydrochloride supplier, inhibitors, inhibits, ubiquitin, isopeptidase, activity, Proteases, Proteinases, NSC632839, hydrochloride, F6, Deubiquitinating, Enzymes, 2647, Tocris Bioscience
2 Citations for NSC 632839 hydrochloride
Citations are publications that use Tocris products. Selected citations for NSC 632839 hydrochloride include:
Zeng et al (2016) CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection. Nature 7 11364 PMID: 27098497
Ryals et al (2018) The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity. Front Cell Neurosci 12 445 PMID: 30532693
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42 perturbagens used the zebrafish DASPEI screen.
By
Anonymous on 12/17/2019
Assay Type: In Vivo
Species: Other
Cell Line/Tissue: larvae
Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound
