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Submit ReviewCL 218872
Description: Benzodiazepine agonist
Chemical Name: 3-Methyl-6-[-3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine
Purity: ≥98% (HPLC)
Biological Activity for CL 218872
CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.
Technical Data for CL 218872
| M. Wt | 278.24 |
| Formula | C13H9F3N4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 66548-69-4 |
| PubChem ID | 107950 |
| InChI Key | GUOQUXNJZHGPQF-UHFFFAOYSA-N |
| Smiles | CC1=NN=C2C=CC(=NN12)C1=CC(=CC=C1)C(F)(F)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CL 218872
References for CL 218872
References are publications that support the biological activity of the product.
Lippa et al (1979) Benzodiazepine receptors: cellular and behavioral characteristics. Pharmacol.Biochem.Behav. 10 831 PMID: 40258
Sieghart (1995) Structure and pharmacology of γ-aminobutyric acidA receptor subtypes. Pharmacol.Rev. 47 181 PMID: 7568326
Squires et al (1979) Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. Pharmacol.Biochem.Behav. 10 825 PMID: 40257
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Keywords: CL 218872, CL 218872 supplier, Benzodiazepine, agonists, GABAA, Receptors, CL218872, 1709, Tocris Bioscience
1 Citation for CL 218872
Citations are publications that use Tocris products. Selected citations for CL 218872 include:
Wang et al (2018) Contribution of the α5 GABAA receptor to the discriminative stimulus effects of PROP in rat. Neuroreport 29 347 PMID: 29369902
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.