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Submit ReviewFlurbiprofen
Description: Cyclooxygenase inhibitor
Chemical Name: 2-Fluoro-α-methyl-[1,1'-biphenyl]-4-acetic acid
Purity: ≥99% (HPLC)
Biological Activity for Flurbiprofen
Flurbiprofen is a potent inhibitor of cyclooxygenase (IC50 values are 0.1 and 0.4 μM for inhibition of human COX-1 and COX-2 respectively). Analgesic, anti-inflammatory and antipyretic in vivo. Inhibits tumor cell growth in vitro and in vivo. Regulates prostate stem cell antigen through activation of Akt kinase. Also inhibits fibroblast proliferation in vitro.
Technical Data for Flurbiprofen
| M. Wt | 244.26 |
| Formula | C15H13FO2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 5104-49-4 |
| PubChem ID | 3394 |
| InChI Key | SYTBZMRGLBWNTM-UHFFFAOYSA-N |
| Smiles | CC(C(O)=O)C1=CC=C(C(F)=C1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Flurbiprofen
References for Flurbiprofen
References are publications that support the biological activity of the product.
Gierse et al (1995) Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem.J. 305 479 PMID: 7832763
Glenn et al (1973) The pharmacology of 2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen). A potent non-steroidal anti-inflammatory drug. Agents Actions 3 210 PMID: 4776365
Hoferova et al (2002) The effect of nonsteroidal antiinflammatory drugs ibuprofen, flurbiprofen, and diclofenac on in vitro and in vivo growth of mouse fibrosarcoma. Cancer Invest. 20 490 PMID: 12094544
Zemskova et al (2006) Gene expression profiling in R-flurbiprofen-treated prostate cancer: R-Flurbiprofen regulates prostate stem cell antigen through activation of AKT kinase. Biochem.Pharmacol. 72 1257 PMID: 16949054
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Keywords: Flurbiprofen, Flurbiprofen supplier, Cyclooxygenase, inhibitors, inhibits, COX, Oxidase, Oxygenases, Oxidases, stem, cells, Akt, kinases, Analgesics, anti-inflammatory, and, antipyretics, Stem, Cell, Signaling, 1769, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Flurbiprofen, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
Citations for Flurbiprofen
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Currently there are no citations for Flurbiprofen.
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Literature in this Area
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