Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewDeguelin
Description: Anticancer and antiviral agent; chemopreventive and pro-apoptotic
Chemical Name: (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
Purity: ≥97% (HPLC)
Biological Activity for Deguelin
Anticancer and antiviral agent; chemopreventive and pro-apoptotic. Inhibits phorbol ester-induced ornithine decarboxylase and NADH:ubiquinone oxidoreductase activities (IC50 values are 11 and 6.9 nM respectively). Inhibits PI 3-kinase and reduces pAkt levels in pre-malignant and malignant human bronchial epithelial cells. Active in vivo.
Technical Data for Deguelin
| M. Wt | 394.42 |
| Formula | C23H22O6 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 522-17-8 |
| PubChem ID | 107935 |
| InChI Key | ORDAZKGHSNRHTD-UXHICEINSA-N |
| Smiles | O=C(C(C=CC5=C4C=CC(C)(C)O5)=C4O3)[C@@]([C@@]3([H])CO2)([H])C1=C2C=C(OC)C(OC)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Deguelin
References for Deguelin
References are publications that support the biological activity of the product.
Chun et al (2003) Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J.Natl.Cancer Inst. 95 291 PMID: 12591985
Fang and Casida (1998) Anticancer action of cube insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities. Proc.Natl.Acad.Sci.U.S.A. 95 3380 PMID: 9520374
Takatsuki et al (1969) Antiviral and antitumor antibiotics. XX. Effects of rotenone, deguelin, and related compounds on animal and plant viruses. Appl.Microbiol. 18 660 PMID: 4312925
Udeani et al (1997) Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid. Cancer Res. 57 3424 PMID: 9270008
View Related Products by Target
Keywords: Deguelin, Deguelin supplier, Anticancer, antiviral, agent, chemopreventive, proapoptotic, Apoptosis, Inducer, Inducers, Non-selective, Antivirals, 1770, Tocris Bioscience
2 Citations for Deguelin
Citations are publications that use Tocris products. Selected citations for Deguelin include:
Hafeez et al (2016) BAD, a Proapoptotic Protein, Escapes ERK/RSK Phosphorylation in Deguelin and siRNA-Treated HeLa Cells. J Neurosci 11 e0145780 PMID: 26745145
Rebolleda et al (2016) Synergistic Activity of Deguelin and fludar. in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model. PLoS One 11 e0154159 PMID: 27101369
Reviews for Deguelin
There are currently no reviews for this product. Be the first to review Deguelin and earn rewards!
Have you used Deguelin?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for Deguelin
