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Submit ReviewSpantide I
Description: Selective NK1 antagonist
Alternative Names: [D-Arg1,D-Trp7,9,Leu11]-Substance P
Biological Activity for Spantide I
Spantide I is a selective NK1 receptor antagonist (Ki values are 230, 8150 and > 10000 nM for rat NK1, NK2 and NK3 receptors respectively). Active in vivo.
Technical Data for Spantide I
| M. Wt | 1497.8 |
| Formula | C75H108N20O13 |
| Sequence |
RPKPQQWFWLL (Modifications: Arg-1 = D-Arg, Trp-7 = Trp-9 = D-Trp) |
| Storage | Desiccate at -20°C |
| CAS Number | 91224-37-2 |
| PubChem ID | 25079075 |
| InChI Key | SAPCBHPQLCZCDV-CHPWDEGWSA-N |
| Smiles | [H]N[C@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Spantide I
References for Spantide I
References are publications that support the biological activity of the product.
Beaujouan et al (1993) Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists. Br.J.Pharmacol. 108 793 PMID: 7682138
Folkers et al (1984) Biological evaluation of substance P antagonists. Br.J.Pharmacol. 83 449 PMID: 6207886
Zubrzycka et al (2000) Comparison of antagonistic properties of substance P analogs, spantide I, II and III, on evoked tongue jerks in rats. Endocr.Regul. 34 13 PMID: 10808247
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Keywords: Spantide I, Spantide I supplier, Selective, NK1, antagonists, Tachykinin, Receptors, Neurokinin, SpantideI, [D-Arg1, D-Trp7, 9, Leu11]-SubstanceP, [D-Arg1,D-Trp7,9,Leu11]-Substance, P, Receptor, 1784, Tocris Bioscience
Citations for Spantide I
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Currently there are no citations for Spantide I.
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Literature in this Area
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