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Submit ReviewVULM 1457
Discontinued Product
2988 has been discontinued.
Description: ACAT inhibitor
Chemical Name: N-[2,6-bis(1-Methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea
Purity: ≥99% (HPLC)
Biological Activity for VULM 1457
VULM 1457 is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor. Decreases cholesterol levels in the plasma and liver of diabetic-hypercholesterolemic rats.
Technical Data for VULM 1457
| M. Wt | 449.57 |
| Formula | C25H27N3O3S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 228544-65-8 |
| PubChem ID | 9933427 |
| InChI Key | XFFITGBWVLQNCD-UHFFFAOYSA-N |
| Smiles | O=C(NC3=C(C(C)C)C=CC=C3C(C)C)NC(C=C2)=CC=C2SC1=CC=C([N+]([O-])=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for VULM 1457
References for VULM 1457
References are publications that support the biological activity of the product.
Adameova et al (2006) Protective effect of SimV. and VULM 1457 in ischaemic-reperfused myocardium of the diabetic-hypercholesterolemic rats. Pharmazie 61 807 PMID: 17020164
Adameova et al (2007) The myocardial infarct size-limiting and antiarrhythmic effects of acyl-CoA: cholesterol acyltransferase inhibitor VULM 1457 protect the hearts of diabetic-hypercholesterolaemic rats against ischaemia/reperfusion injury both in vitro and in v Eur.J.Pharmacol. 576 114 PMID: 17764671
Vojtassakova et al (2007) Effect of VULM 1457, an ACAT inhibitor, on serum lipid levels and on real time red blood cell flow in diabetic and non-diabetic hamsters fed high cholesterol-lipid diet. Gen.Physiol.Biophys. 26 254 PMID: 18281742
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Keywords: VULM 1457, VULM 1457 supplier, Acyl-CoA, cholesterol, acyltransferase, ACAT, inhibitors, inhibits, Transferases, VULM1457, Acyl-CoA:Cholesterol, Acyltransferase, 2988, Tocris Bioscience
Citations for VULM 1457
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Currently there are no citations for VULM 1457.
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