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Submit ReviewAltanserin hydrochloride
Description: 5-HT2A receptor antagonist
Chemical Name: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Altanserin hydrochloride
Altanserin hydrochloride is a potent and selective 5-HT2A receptor antagonist (Ki values are 0.13, 4.55, 40, 62 and 1570 nM at 5-HT2A, α1, 5-HT2C, D2 and 5-HT1A respectively). Centrally active following systemic administration in vivo.
Compound Libraries for Altanserin hydrochloride
Altanserin hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Altanserin hydrochloride
| M. Wt | 447.95 |
| Formula | C22H22FN3O2S.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1135280-78-2 |
| PubChem ID | 24978536 |
| InChI Key | JFPPLMAMMZZOEA-UHFFFAOYSA-N |
| Smiles | Cl.FC1=CC=C(C=C1)C(=O)C1CCN(CCN2C(=S)NC3=CC=CC=C3C2=O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Altanserin hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.96 | 20 with gentle warming |
Preparing Stock Solutions for Altanserin hydrochloride
The following data is based on the product molecular weight 447.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.16 mL | 55.81 mL | 111.62 mL |
| 1 mM | 2.23 mL | 11.16 mL | 22.32 mL |
| 2 mM | 1.12 mL | 5.58 mL | 11.16 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.23 mL |
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Product Datasheets for Altanserin hydrochloride
References for Altanserin hydrochloride
References are publications that support the biological activity of the product.
Herth et al (2009) Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET. Bioorg.Med.Chem. 17 2989 PMID: 19329329
Kennett et al (1994) Evidence that 5-HT2C receptor antagonists are anxiolytic in the rat Geller-Seifter model of anxiety. Psychopharmacology 114 90 PMID: 7846211
Koenig et al (1987) Stimulation of corticosterone and β-endorphin secretion in the rat by selective 5-HT receptor subtype activation. Eur.J.Pharmacol. 137 1 PMID: 2956114
Sietnick (1985) Involvement of 5-HT2 receptors in the LSD- and L-5-HTP-induced suppression of lordotic behavior in the female rat. J.Neural Transm. 61 65 PMID: 3872342
If you know of a relevant reference for Altanserin hydrochloride, please let us know.
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Keywords: Altanserin hydrochloride, Altanserin hydrochloride supplier, 5-HT2A, receptor, antagonists, Serotonin, Receptors, 1809, Tocris Bioscience
2 Citations for Altanserin hydrochloride
Citations are publications that use Tocris products. Selected citations for Altanserin hydrochloride include:
Yu and Yamaguchi (2009) 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations. J Neurophysiol 102 752 PMID: 19474172
Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. Am J Physiol Regul Integr Comp Physiol 6 e21395 PMID: 21789169
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.