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Submit ReviewHS 014
Description: Selective MC4 receptor antagonist
Purity: ≥95% (HPLC)
Biological Activity for HS 014
HS 014 is a potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and nociception in mice following central administration in vivo. Also inhibits IL-1β-induced Fos expression in the paraventricular hypothalamus.
Technical Data for HS 014
| M. Wt | 1563.77 |
| Formula | C71H94N20O17S2 |
| Sequence |
CEHXRWGCPPKD (Modifications: Cys-1 = N-terminal Ac, X = D-2-Nal, Asp-12 = C-terminal amide, Disulfide bridge: 1-8) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 207678-81-7 |
| PubChem ID | 24821295 |
| InChI Key | BRGDPINZISNYJL-VMAVSDBDSA-N |
| Smiles | CC(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for HS 014
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for HS 014
References for HS 014
References are publications that support the biological activity of the product.
Bellasio et al (2003) Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur.J.Pharmacol. 482 127 PMID: 14660013
Schioth et al (1998) Discovery of novel melanocortin4 receptor selective MSH analogues. Br.J.Pharmacol. 124 75 PMID: 9630346
Whitaker and Reye (2008) Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1β administration. Neuropharmacology 54 509 PMID: 18082228
If you know of a relevant reference for HS 014, please let us know.
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Keywords: HS 014, HS 014 supplier, Selective, MC4R, receptor, antagonists, Receptors, Melanocortin, HS014, 1831, Tocris Bioscience
1 Citation for HS 014
Citations are publications that use Tocris products. Selected citations for HS 014 include:
Panaro et al (2014) The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. PLoS One 20 1018 PMID: 25453189
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.