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Submit ReviewSD 169
Description: Selective, orally active p38α inhibitor
Chemical Name: 1H-Indole-5-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for SD 169
Selective, orally active, ATP-competitive inhibitor of p38α MAPK (IC50 values are 3.2, 122 and > 50000 nM for p38α, p38β and p38γ respectively). Demonstrates no activity against a range of other kinases including ERK2, JNK1 and MAPKAP2. Prevents development of diabetes and alleviates mild and moderate hyperglycaemic states in NOD mice.
Technical Data for SD 169
| M. Wt | 160.17 |
| Formula | C9H8N2O |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1670-87-7 |
| Smiles | NC(C1=CC=C(NC=C2)C2=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SD 169
References for SD 169
References are publications that support the biological activity of the product.
Myers et al (2003) Inhibition of p38 MAP kinase activity enhances axonal regeneration. Exp.Neurol. 184 606 PMID: 14769353
Medicherla et al (2006) Preventive and therapeutic potential of p38α-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. J.Pharmacol.Exp.Ther. 318 99 PMID: 16603672
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Citations for SD 169
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Currently there are no citations for SD 169.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for SD 169
