Ipsapirone

Pricing Availability   Qty
Description: Selective 5-HT1A agonist
Alternative Names: TVX Q 7821
Chemical Name: 2-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one-1,1-dioxide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (3)

Biological Activity for Ipsapirone

Ipsapirone is a selective 5-HT1A receptor agonist (Ki = 10 nM). Anxiolytic in vivo.

Technical Data for Ipsapirone

M. Wt 401.48
Formula C19H23N5O3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 95847-70-4
PubChem ID 56971
InChI Key TZJUVVIWVWFLCD-UHFFFAOYSA-N
Smiles O=C1N(CCCCN2CCN(CC2)C2=NC=CC=N2)S(=O)(=O)C2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ipsapirone

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.01 10

Preparing Stock Solutions for Ipsapirone

The following data is based on the product molecular weight 401.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.91 mL 124.54 mL 249.08 mL
0.5 mM 4.98 mL 24.91 mL 49.82 mL
1 mM 2.49 mL 12.45 mL 24.91 mL
5 mM 0.5 mL 2.49 mL 4.98 mL

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Product Datasheets for Ipsapirone

Certificate of Analysis / Product Datasheet
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References for Ipsapirone

References are publications that support the biological activity of the product.

Maj et al (1987) Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and DArgic functions. J.Neural.Transm. 70 1 PMID: 2889795

Glaser and Traber (1985) Binding of the putative anxiolytic TVX Q 7821 to hippocampal 5-hydroxytryptamine (5-HT) recognition sites. Naunyn-Schmied.Arch.Pharmacol. 329 211

Traber et al (1984) Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821. Brain Res.Bull. 12 741 PMID: 6541079


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Keywords: Ipsapirone, Ipsapirone supplier, Selective, 5-HT1A, agonists, Serotonin, Receptors, TVXQ7821, TVX, Q, 7821, 1869, Tocris Bioscience

2 Citations for Ipsapirone

Citations are publications that use Tocris products. Selected citations for Ipsapirone include:

Rozeske et al (2011) Uncontrollable, but not controllable, stress desensitizes 5-HT1A receptors in the dorsal raphe nucleus. J Neurosci 31 14107 PMID: 21976495

Borroto-Escuela et al (2017) Existence of Brain 5-HT1A-5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor-Receptor Interactions Regulating 5-HT1A Receptor Recognition. ACS Omega 2 4779 PMID: 28920103


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Reviews for Ipsapirone

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.