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Soluble amyloid β-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17.
M. Wt | 1446.67 |
Formula | C71H99N17O16 |
Sequence | YEVHHQKLVFF |
Storage | Desiccate at -20°C |
CAS Number | 152286-31-2 |
Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Miyazaki et al (1993) A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor. Nature 362 839 PMID: 8479521
Roher et al (1994) Proteolysis of Aβ peptide from Alzheimer disease brain by gelatinase A. Biochem.Biophys.Res.Commun. 205 1755 PMID: 7811262
Keywords: Amyloid b-peptide (10-20) (human), Amyloid b-peptide (10-20) (human) supplier, β-Amyloid, beta-Amyloid, b-amyloid, β-peptide, beta-peptide, fragment, substrates, gelatinase, A, type, IV, collagenase, MMP-2, metalloproteinase, metalloprotease, amyloid, precursor, protein, APP, secretase, Amyloid, beta, peptide, (10-20), (human), amyloidbeta, b-AP, Beta, Peptides, Enzyme, Substrates, /, Activators, Matrix, Metalloprotease, Other, Proteases, 1892, Tocris Bioscience
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