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Submit ReviewAmyloid β-Peptide (12-28) (human)
Discontinued Product
1894 has been discontinued.
Description: Amyloid β-peptide; minimum required for binding to brain proteins
Biological Activity for Amyloid β-Peptide (12-28) (human)
Amyloid β-Peptide (12-28) (human) is an amyloid β-peptide fragment; minimum section required to bind to brain proteins. Binds with high affinity to α7-nicotinic ACh receptors, and impairs memory retention following central administration in mice in vivo.
Technical Data for Amyloid β-Peptide (12-28) (human)
| M. Wt | 1955.2 |
| Formula | C89H135N25O25 |
| Sequence | VHHQKLVFFAEDVGSNK |
| Storage | Desiccate at -20°C |
| CAS Number | 107015-83-8 |
| PubChem ID | 24868224 |
| InChI Key | WOMPQPMHRDDZMP-IJBWYZRXSA-N |
| Smiles | [H]N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Amyloid β-Peptide (12-28) (human)
References for Amyloid β-Peptide (12-28) (human)
References are publications that support the biological activity of the product.
Flood et al (1994) An amyloid β-protein fragment, A b[12-28], equipotent impairs post-training memory processing when injected into different limbic system structures. Brain Res. 663 271 PMID: 7874511
Freir and Herron (2003) Nicotine enhances the depressive actions of A β 1-40 on long-term potentiation in the rat hippocampal CA1 region in vivo. J.Neurophysiol. 89 2917 PMID: 12611941
Ray et al (1998) Binding of amyloid b-protein to intracellular brain proteins in rat and human. Neurochem.Res. 23 1277 PMID: 9804283
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Citations for Amyloid β-Peptide (12-28) (human)
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