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Submit ReviewGuanylin (human)
Description: Endogenous activator of intestinal guanylyl cyclase
Purity: ≥95% (HPLC)
Biological Activity for Guanylin (human)
Guanylin (human) is an endogenous peptide activator of intestinal guanylyl cyclase; secreted mainly by the gastrointestinal mucosa. Regulates water and electrolyte transport in intestinal and renal epithelia.
Technical Data for Guanylin (human)
| M. Wt | 1458.65 |
| Formula | C58H87N15O21S4 |
| Sequence |
PGTCEICAYAACTGC (Modifications: Disulfide Bridges: 4-12, 7-15) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 183200-12-6 |
| PubChem ID | 90488722 |
| InChI Key | XPNQMTAYRNMRRD-RDJGHUJSSA-N |
| Smiles | [H]N1CCC[C@H]1C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](C)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC2=O)[C@@H](C)O)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC1=O)[C@@H](C)CC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Guanylin (human)
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Guanylin (human)
References for Guanylin (human)
References are publications that support the biological activity of the product.
Beltowski (2001) Guanylin and related peptides. J.Physiol.Pharmacol. 52 351 PMID: 11596856
Currie et al (1992) Guanylin: an endogenous activator of intestinal guanylate cyclase. Proc.Natl.Acad.Sci.U.S.A. 89 947 PMID: 1346555
Nokihara et al (1997) Synthesis, solution structure, binding activity, and cGMP activation of human guanylin and its disulfide isomer. Regul.Pept. 70 111 PMID: 9272623
If you know of a relevant reference for Guanylin (human), please let us know.
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Keywords: Guanylin (human), Guanylin (human) supplier, Endogenous, activators, intestinal, guanylyl, cyclase, sGC, Guanylyl, cyclases, Cyclase, 1898, Tocris Bioscience
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