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Submit ReviewVIP (human, rat, mouse, rabbit, canine, porcine)
Description: Involved in neurotransmission and smooth muscle relaxation
Alternative Names: Vasoactive Intestinal Peptide (human,rat,mouse,rabbit,canine,porcine)
Purity: ≥95% (HPLC)
Biological Activity
VIP (human, rat, mouse, rabbit, canine, porcine) is a neuropeptide with many biological actions; plays a role in neurotransmission, smooth muscle relaxation and has trophic and mitogenic actions.
Technical Data
| M. Wt | 3325.83 |
| Formula | C147H238N44O42S |
| Sequence |
HSDAVFTDNYTRLRKQMAVKKYLNSILN (Modifications: Asn-28 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 40077-57-4 |
| PubChem ID | 16140438 |
| InChI Key | HEOYHMUESMJFDC-RIWXPGAOSA-N |
| Smiles | [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets
References
References are publications that support the biological activity of the product.
Harmar et al (1998) International Union of Pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. Pharmacol.Rev. 50 265 PMID: 9647867
Laburthe and Couvineau (2002) Molecular pharmacology and structure of VPAC receptors for VIP and PACAP. Regul.Pept. 108 165 PMID: 12220741
If you know of a relevant reference for VIP (human, rat, mouse, rabbit, canine, porcine), please let us know.
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Keywords: VIP (human, rat, mouse, rabbit, canine, porcine), VIP (human, rat, mouse, rabbit, canine, porcine) supplier, Involved, neurotransmission, smooth, muscle, relaxation, Vasoactive, Intestinal, Peptide, Receptors, VPAC, VIP, agonists, (human,, rat,, mouse,, rabbit,, canine,, porcine), 1911, Tocris Bioscience
3 Citations for VIP (human, rat, mouse, rabbit, canine, porcine)
Citations are publications that use Tocris products. Selected citations for VIP (human, rat, mouse, rabbit, canine, porcine) include:
Gey et al (2016) Atf3 mutant mice show reduced axon regeneration and impaired regeneration-associated gene induction after peripheral nerve injury. Open Biol 6 PMID: 27581653
Alcolado et al (2014) Cystic fibrosis transmembrane conductance regulator dysfunction in VIP knockout mice. Am J Physiol Cell Physiol 307 C195 PMID: 24898584
Piet et al (2016) Vasoactive Intestinal Peptide Excites GnRH Neurons in Male and Female Mice. Endocrinology. 157 3621 PMID: 27501185
Do you know of a great paper that uses VIP (human, rat, mouse, rabbit, canine, porcine) from Tocris? Please let us know.
Reviews for VIP (human, rat, mouse, rabbit, canine, porcine)
Average Rating: 5 (Based on 1 Review.)
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By
Jacob Painter on 07/07/2022
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Lymphoid Cells
Used in vitro. Was able to stimulate at 1 uM. Was easy to reconstitute.