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Submit Review[D-Lys3]-GHRP-6
Description: Ghrelin receptor antagonist
Purity: ≥95% (HPLC)
Biological Activity for [D-Lys3]-GHRP-6
[D-Lys3]-GHRP-6 is an antagonist at the ghrelin receptor (GHS-R1a) (IC50 = 0.9 μM). Also weakly binds to melanocortin receptors (Ki = 26-120 μM). Centrally active in vivo.
Technical Data for [D-Lys3]-GHRP-6
| M. Wt | 930.12 |
| Formula | C49H63N13O6 |
| Sequence |
HWKWFK (Modifications: Trp-2 = D-Trp, Lys-3 = D-Lys, Phe-5 = D-Phe, Lys-6 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 136054-22-3 |
| PubChem ID | 5311279 |
| InChI Key | MGSNWNLPMHXGDD-DFWOJPNQSA-N |
| Smiles | [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for [D-Lys3]-GHRP-6
| Solubility | Soluble to 0.50 mg/ml in water |
Product Datasheets for [D-Lys3]-GHRP-6
References for [D-Lys3]-GHRP-6
References are publications that support the biological activity of the product.
Pinilla et al (2003) Role of ghrelin in the control of GH secretion in prepubertal rats: interactions with excitatory amino acids. Neuroendocrinology 77 83 PMID: 12624529
Schioth et al (1997) Characterization of the binding of MSH-B, HP-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31 565 PMID: 9574823
Traebert et al (2002) Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. J.Neuroendocrinol. 14 580 PMID: 12121496
If you know of a relevant reference for [D-Lys3]-GHRP-6, please let us know.
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Keywords: [D-Lys3]-GHRP-6, [D-Lys3]-GHRP-6 supplier, Ghrelin, receptors, antagonists, GHS-R1a, Growth, Hormone, Secretagog, 1a, Receptors, 1922, Tocris Bioscience
6 Citations for [D-Lys3]-GHRP-6
Citations are publications that use Tocris products. Selected citations for [D-Lys3]-GHRP-6 include:
Gomez and (2014) The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL/6J mice. Alcohol Clin Exp Res 38 2436 PMID: 25257292
Kemp et al (2011) Intrarenal ghrelin infusion stimulates distal nephron-dependent sodium reabsorption in normal rats. PLoS Comput Biol 57 633 PMID: 21220707
Murtuza and Isokawa (2018) Endogenous ghrelin-O-acyltransferase (GOAT) acylates local ghrelin in the hippocampus. J Neurochem 144 58 PMID: 29063591
Hashiguchi (2017) Direct versus indirect actions of ghrelin on hypothalamic NPY neurons. PLoS One 12 e0184261 PMID: 28877214
Kamei et al (2017) Rikkunshito prevents PacT.-induced peripheral neuropathy through the suppression of the nuclear factor kappa B (NFκB) phosphorylation in spinal cord of mice. PLoS One 12 e0171819 PMID: 28182729
Song et al (2013) Ghrelin modulates lateral amygdala neuronal firing and blocks acquisition for conditioned taste aversion. PLoS One 8 e65422 PMID: 23762368
Do you know of a great paper that uses [D-Lys3]-GHRP-6 from Tocris? Please let us know.
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.