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Submit ReviewMelanocyte-stimulating hormone release inhibiting factor
Description: Inhibitor of α-MSH release; inhibits opioid effects in vivo
Alternative Names: Pro-Leu-Gly amide,MIF-I,PLG
Biological Activity
Melanocyte-stimulating hormone release inhibiting factor is a inhibitor of melanocyte-stimulating hormone (MSH) release. Blocks the release of α-MSH, increases brain dopamine levels and antagonizes physiological and behavioral opioid effects in vivo.
Technical Data
| M. Wt | 284.36 |
| Formula | C13H24N4O3 |
| Sequence |
PLG (Modifications: Gly-3 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 2002-44-0 |
| PubChem ID | 92910 |
| InChI Key | NOOJLZTTWSNHOX-UWVGGRQHSA-N |
| Smiles | [H]N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
References
References are publications that support the biological activity of the product.
Kavaliers and Hirst (1986) Inhibitory influences of FMRFamide and PLG on stress-induced opioid analgesia and activity. Brain Res. 372 370 PMID: 2871903
Mishra et al (1983) Pharmacology of L-Prolyl-L-Leucyl-Glycinamide (PLG): a review. Methods Find.Exp.Clin.Pharmacol. 5 203 PMID: 6136640
Plotnikoff and Kastin (1974) Pharmacological studies with a tripeptide, Prolyl-Leucyl Glycine amide. Arch.Int.Pharmacodyn.Ther. 211 211 PMID: 4156639
Pugsley and Lippmann (1977) Synthetic melanocyte stimulating hormone release inhibiting factor (MIF). Part III: effect of L-prolyl-N-MthD.-leucyl-glycinamide and MIF on biogenic amine turnover. Arzneimittelforschung 27 2293 PMID: 23796
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Keywords: Melanocyte-stimulating hormone release inhibiting factor, Melanocyte-stimulating hormone release inhibiting factor supplier, α-MSH, alpha-MSH, a-MSH, release, inhibits, inhibitors, melanocortin, receptors, Pro-Leu-Gly, amide, MIF-I, PLG, Miscellaneous/Non-selective, Opioids, Dopaminergic-Related, Melanocortin, Receptors, 1929, Tocris Bioscience
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.