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Submit ReviewNSC 693868
Description: Cdk inhibitor; also inhibits GSK-3
Chemical Name: 1H-Pyrazolo[3,4-b]quinoxalin-3-amine
Purity: ≥99% (HPLC)
Biological Activity for NSC 693868
Cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 0.4, 0.6, 4.4 - 5.6 μM for cdk5, cdk1 and cdk2, respectively). Also inhibits GSK-3 (IC50 = 1 uM).
Technical Data for NSC 693868
| M. Wt | 185.19 |
| Formula | C9H7N5 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 40254-90-8 |
| PubChem ID | 438981 |
| InChI Key | DWHVZCLBMTZRQM-UHFFFAOYSA-N |
| Smiles | NC1=NN=C2NC3=CC=CC=C3N=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NSC 693868
References for NSC 693868
References are publications that support the biological activity of the product.
Ortega et al (2002) Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorg.Med.Chem.Lett. 10 2177 PMID: 11983514
Monge et al (1995) 3-Amino-2-quinoxalinecarbonitrile. New fused quinoxalines with potential cytotoxic activity. J.Heterocycl.Chem. 31 1135
Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987
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Keywords: NSC 693868, NSC 693868 supplier, GSK-3, inhibitors, inhibits, cdks, GSK, Glycogen, Synthase, Kinases, 3, Cyclin-Dependent, Protein, Carbohydrate, Metabolism, NSC693868, Cyclin-dependent, Kinase, 1937, Tocris Bioscience
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Cell Cycle and DNA Damage Research Product Guide
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.