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Submit ReviewLoratidine
Discontinued Product
1944 has been discontinued.
View all Histamine H<sub>1</sub> Receptors products.
Description: Peripheral H1 antagonist; antiallergic agent
Alternative Names: SCH 29851
Chemical Name: 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Biological Activity for Loratidine
Loratidine is a peripheral histamine H1 receptor antagonist (Ki = 35 nM); devoid of central effects. Orally active antiallergic agent.
Compound Libraries for Loratidine
Loratidine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Loratidine
| M. Wt | 382.88 |
| Formula | C22H23ClN2O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 79794-75-5 |
| PubChem ID | 3957 |
| InChI Key | JCCNYMKQOSZNPW-UHFFFAOYSA-N |
| Smiles | CCOC(=O)N1CC\C(CC1)=C1/C2=NC=CC=C2CCC2=C1C=CC(Cl)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Loratidine
Safety Datasheet is currently unavailable on-line.
Please contact Customer Service.
Please contact Customer Service.
References for Loratidine
References are publications that support the biological activity of the product.
Ahn and Barnett (1986) Selective displacement of [3H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamine. Eur.J.Pharmacol. 127 153 PMID: 2875889
Barnett et al (1984) Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamine. Agents Actions 14 590 PMID: 6236679
Kreutner et al (1987) Antiallergic activity of loratidine, a non-sedating antihistamine. Allergy 42 57 PMID: 2436504
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Keywords: Loratidine, Loratidine supplier, Peripheral, H1, antagonists, anti-allergic, agent, Receptors, Histamine, histaminergic, SCH29851, SCH, 29851, 1944, Tocris Bioscience
Citations for Loratidine
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Currently there are no citations for Loratidine.
Reviews for Loratidine
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.