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Submit ReviewNomifensine
Description: Potent noradrenalin and dopamine uptake inhibitor. Antidepressant
Chemical Name: 1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine maleate
Purity: ≥98% (HPLC)
Biological Activity for Nomifensine
Nomifensine is a potent inhibitor of noradrenaline and dopamine uptake (Ki values are 4.7, 26 and 4000 nM for inhibition of noradrenaline, dopamine and 5-HT uptake respectively, in rat brain). Increases central dopamine levels in rats following systemic administration. Displays antidepressant activity.
Technical Data for Nomifensine
| M. Wt | 354.4 |
| Formula | C16H18N2.C4H4O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 32795-47-4 |
| PubChem ID | 5358907 |
| InChI Key | GEOCVSMCLVIOEV-BTJKTKAUSA-N |
| Smiles | NC1=CC=CC2=C1C[N+]([H])(C)CC2C3=CC=CC=C3.O=C(O)\C=C/C([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Nomifensine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.44 | 100 |
Preparing Stock Solutions for Nomifensine
The following data is based on the product molecular weight 354.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.82 mL | 14.11 mL | 28.22 mL |
| 5 mM | 0.56 mL | 2.82 mL | 5.64 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.82 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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Product Datasheets for Nomifensine
References for Nomifensine
References are publications that support the biological activity of the product.
Tuomisto (1977) Nomifensine and its derivatives as possible tools for studying amine uptake. Eur.J.Pharmacol. 42 101 PMID: 844493
Nakachi et al (1995) Effects of various DA uptake inhibitors on striatal extracellular DA levels and behaviours in rats. Eur.J.Pharmacol. 281 195 PMID: 7589207
Katz et al (2010) Effects of acute and sustained administration of the catecholamine reuptake inhibitor nomifensine on the firing activity of monoaminergic neurons. J.Psychopharmacol. 24 1223 PMID: 19939862
If you know of a relevant reference for Nomifensine, please let us know.
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Keywords: Nomifensine, Nomifensine supplier, noradrenaline, noradrenalin, norepinephrine, NET, DAT, transporter, transports, dopamine, reuptake, uptake, inhibitors, inhibits, antidepressants, anti-depressants, depression, Adrenergic, Transporters, Dopamine, 1992, Tocris Bioscience
1 Citation for Nomifensine
Citations are publications that use Tocris products. Selected citations for Nomifensine include:
Zapata et al (2007) Regulation of DA transporter function and cell surface expression by D3 DA receptors. J Biol Chem 282 35842 PMID: 17923483
Do you know of a great paper that uses Nomifensine from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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