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Submit Review(±)-Cloprostenol sodium salt
Description: Water-soluble PGF2α analog and potent FP receptor agonist
Chemical Name: (5Z)-rel-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-butenyl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid monosodium salt
Purity: ≥98% (HPLC)
Biological Activity for (±)-Cloprostenol sodium salt
(±)-Cloprostenol sodium salt is a water-soluble prostaglandin F2α (PGF2α) analog; acts as a potent FP receptor agonist (EC50 = 0.84 nM). Potently inhibits differentiation of adipocyte precursor cells. Luteolytic agent in vivo.
Technical Data for (±)-Cloprostenol sodium salt
| M. Wt | 446.9 |
| Formula | C22H28ClNaO6 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 55028-72-3 |
| PubChem ID | 17756794 |
| InChI Key | IFEJLMHZNQJGQU-KXXGZHCCSA-M |
| Smiles | [Na+].O[C@@H](COC1=CC(Cl)=CC=C1)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (±)-Cloprostenol sodium salt
References for (±)-Cloprostenol sodium salt
References are publications that support the biological activity of the product.
Dukes et al (1974) Potent luteolytic agents related to prostaglandin F2α. Nature 250 330 PMID: 4853720
Griffin et al (1998) Pharmacological characterization of an FP prostaglandin receptor on rat vascular smooth muscle cells (A7r5) coupled to phosphoinositide turnover and intracellular calcium mobilization. J.Pharmacol.Exp.Ther. 286 411 PMID: 9655886
Serrero and Lepak (2002) Prostaglandin F2α receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined medium. Biochem.Biophys.Res.Comm. 233 200
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Keywords: (±)-Cloprostenol sodium salt, (±)-Cloprostenol sodium salt supplier, Water-soluble, PGF2alpha, potent, FP, receptor, agonists, Receptors, Prostaglandin, Prostanoid, 2295, Tocris Bioscience
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