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Submit Review(R)-(+)-Methanandamide (in Tocrisolve™ 100)
Description: Potent and selective CB1 agonist; supplied in water-soluble emulsion
Chemical Name: (R)-N-(2-Hydroxy-1-methylethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Biological Activity
Stable anandamide analog that is a selective agonist for the CB1 receptor (Ki values are 20 and 815 nM for CB1 and CB2 receptors respectively), in water-soluble emulsion (for details see TocrisolveTM 100). Displays agonist activity at vanilloid receptors.
(R)-(+)-Methanandamide, pure oil dissolved in ethanol and Tocrisolve Control also available.
Technical Data
| M. Wt | 361.57 |
| Formula | C23H39NO2 |
| Storage | Store at +4°C |
| CAS Number | 157182-49-5 |
| PubChem ID | 6321351 |
| InChI Key | SQKRUBZPTNJQEM-FQPARAGTSA-N |
| Smiles | O=C(N[C@H](C)CO)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
References
References are publications that support the biological activity of the product.
Abadji et al (1994) (R)-Methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability. J.Med.Chem. 37 1889 PMID: 8021930
Carriero et al (1998) A detailed characterization of the effects of four cannabinoid agonists on operant lever pressing. Psychopharmacology (Berl.) 137 147 PMID: 9630001
Khanolkar et al (1996) Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand. J.Med.Chem. 39 4515 PMID: 8893848
Zygmunt et al (1999) Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400 452 PMID: 10440374
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Keywords: (R)-(+)-Methanandamide (in TocrisolveTM 100), (R)-(+)-Methanandamide (in TocrisolveTM 100) supplier, Potent, selective, CB1, agonists, water-soluble, emulsion, cannabinoids, Receptors, cb1r, TocrisolveTM100, 1782, Tocris Bioscience
3 Citations for (R)-(+)-Methanandamide (in Tocrisolve™ 100)
Citations are publications that use Tocris products. Selected citations for (R)-(+)-Methanandamide (in Tocrisolve™ 100) include:
Garzón et al (2009) Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with mor. Mol Pain 5 11 PMID: 19284549
Grace et al (2014) Identification of a pharmacological target for genioglossus reactivation throughout sleep. Int J Neuropsychopharmacol 37 41 PMID: 24470694
Sánchez-Blázquez et al (2014) The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. J Neuroimmune Pharmacol 17 1943 PMID: 24485144
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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