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Description: Competitive and GluN2A-selective NMDA antagonist
Alternative Names: LY 257883
Chemical Name: (2R*,4S*)-4-(3-Phosphonopropyl)-2-piperidinecarboxylic acid
Biological Activity for PPPA
PPPA is a competitive NMDA receptor antagonist that displays moderate selectivity for NR2A-containing receptors (Ki values are 0.13, 0.47, 1.10 and 3.86 μM for GluN2A, GluN2B, GluN2C and GluN2D subunits respectively).
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Technical Data for PPPA
| M. Wt | 251.22 |
| Formula | C9H18NO5P |
| Storage | Desiccate at RT |
| CAS Number | 113190-92-4 |
| PubChem ID | 90488757 |
| InChI Key | GPFGYOMXVORLFH-RXZNUWRWSA-N |
| Smiles | O=P(CCC[C@@H]1C[C@H]([C@](O)=O)NCC1)(O)O.O=C([C@H]2NCC[C@@H](CCCP(O)(O)=O)C2)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PPPA
References for PPPA
References are publications that support the biological activity of the product.
Benveniste and Mayer (1992) Effect of extracellular pH on the potency of N-MthD.-aspartic acid receptor competitive antagonists. Mol.Pharmacol. 42 679 PMID: 1435743
Feng et al (2005) The effect of competitive antagonist chain length on NMDA receptor subunit selectivity. Neuropharmacology 48 354 PMID: 15721167
Kinarsky et al (2005) Identification of subunit- and antagonist-specific amino acid residues in the N-MthD.-aspartate receptor glutamate-binding pocket. J.Pharmacol.Exp.Ther. 313 1066 PMID: 15743930
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Keywords: PPPA, PPPA supplier, Competitive, NR2A, antagonists, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, LY257883, GluN2A, GluN2B, LY, 257883, 2274, Tocris Bioscience
1 Citation for PPPA
Citations are publications that use Tocris products. Selected citations for PPPA include:
Liu et al (2015) The distinct role of NR2B subunit in the enhancement of visual plasticity in adulthood. Mol Brain 8 49 PMID: 26282667
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