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Enterostatin

Cat. No. 3612 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3612 has been discontinued.

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说明： Binds to β-subunit of F1-ATPase; anorexigenic peptide
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for Enterostatin

N' terminal peptide fragment of procolipase that binds to the β-subunit of F1-ATPase. Activates the ERK and cAMP signaling pathways, and downregulates expression of Krüppel-like factor 4 (KLF4) and agouti-related peptide (AgRP) in vitro. Inhibits insulin secretion from pancreatic β-cells by downregulating expression of dynamin2 and altering protein trafficking. Reduces dietary fat intake via activation of CCK1, induces satiety, enhances memory-consolidation and exhibits hypocholesterolemic activity in vivo. Orally active.

技术数据 for Enterostatin

分子量 496.57
公式 C21H36N8O6
序列 APGPR
储存 Store at -20°C
CAS Number 117830-79-2
Smiles [H]N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Enterostatin

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化学品安全技术说明书

参考文献 for Enterostatin

参考文献是支持产品生物活性的出版物。

Takenaka et al (2008) Enterostatin reduces serum cholesterol levels by way of a CCK(1) receptor-dependent mechanism. Peptides 29 2175 PMID: 18824202

Park et al (2009) Enterostatin affects cyclic AMP and ERK signaling pathways to regulate Agouti-related Protein (AgRP) expression. Peptides 30 181 PMID: 19059445

Park et al (2009) Enterostatin alters protein trafficking to inhibit Ins secretion in Beta-TC6 cells. Peptides 30 1866 PMID: 19563849

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关键词: Enterostatin, Enterostatin supplier, Binds, β-subunit, beta-subunit, F1-ATPase, anorexigenic, peptide, activators, CCK1, reduces, dietary, fat, intake, P-Type, ATPase, V-Type, E-Type, F-Type, ATPases, GTPases, Oxidative, phosphorylation, Cholecystokinin1, Receptors, CCK, Cholecystokinin, H+-ATPase, Receptor, Phosphorylation, 3612, Tocris Bioscience

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