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Submit Reviewγ1-MSH
说明： Selective MC3 receptor agonist
生物活性 for γ1-MSH
γ1-MSH is an endogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exhibits hypertensive, tachycardic and short-term analgesic activity in vivo.
技术数据 for γ1-MSH
| 分子量 | 1512.76 |
| 公式 | C72H97N21O14S |
| 序列 |
YVMGHFRWDRF (Modifications: Phe-11 = C-terminal amide) |
| 储存 | Store at -20°C |
| CAS Number | 72629-65-3 |
| PubChem ID | 57339641 |
| InChI Key | SLEIICTWQFRIFM-SLNSXFHGSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for γ1-MSH
参考文献 for γ1-MSH
参考文献是支持产品生物活性的出版物。
Versteeg et al (1998) Melanocortins and cardiovascular regulation. Eur.J.Pharmacol. 360 1 PMID: 9845266
Lindblom et al (1998) Autoradiographic discrimination of melanocortin receptors indicates that the MC3 subtype dominates in the medial rat brain. Brain Res. 810 161 PMID: 9813305
Jansone et al (2004) Opposite effects of γ1- and γ2-melanocyte stimulating hormone on regulation of the DArgic mesolimbic system in rats. Neurosci.Lett. 361 68 PMID: 15135895
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关键词: gamma1-MSH, gamma1-MSH supplier, Selective, MC3R, receptor, agonists, Receptors, Melanocortin, γ1-MSH, gamma1-MSH, 3424, Tocris Bioscience
1 篇 γ1-MSH 的引用文献
引用文献是使用了 Tocris 产品的出版物。 γ1-MSH 的部分引用包括：
Nøhr et al (2017) The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int 102 105 PMID: 27916541
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