Ginkgolic Acid

Name: Ginkgolic Acid
Brand: Tocris Bioscience
SKU: 6326

Cat. No. 6326 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6326 has been discontinued.

View all Other Ligases products.

说明： Inhibits SUMOylation by binding E1

化学名： 2-Hydroxy-6-(8Z)-8-pentadecenylbenzoic acid

纯度： ≥97% (HPLC)

说明书

引用文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Ginkgolic Acid

Ginkgolic Acid is an inhibitor of SUMOylation (IC₅₀ = 3 μM). Directly binds E1 and inhibits formation of E1-SUMO intermediate. Protects against amyloid β-induced impairment of neurotransmission and synaptic plasticity. Also suppresses CD44 and MMP14 expression in breast cancer cells, eliminating cancer stem cells and inhibiting tumorigenesis.

技术数据 for Ginkgolic Acid

分子量	346.5
公式	C₂₂H₃₄O₃
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	22910-60-7
PubChem ID	5281858
InChI Key	YXHVCZZLWZYHSA-FPLPWBNLSA-N
Smiles	CCCCCC/C=C\CCCCCCCC1=C(C(O)=CC=C1)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Ginkgolic Acid

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ginkgolic Acid

参考文献是支持产品生物活性的出版物。

Fukuda et al (2009) Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Chem.Biol. 16 133 PMID: 19246003

Mango et al (2016) Ginkgolic acid protects against Aβ-induced synaptic dysfunction in the hippocampus. Front.Pharmacol. 7 401 PMID: 27833555

Bogachek et al (2016) Inhibiting the SUMO pathway represses the cancer stem cell population in breast and colorectal carcinomas. Stem Cell Reports. 7 1140 PMID: 27916539

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