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Submit ReviewNF 340
说明： Selective P2Y11 antagonist
化学名： 4,4'-(Carbonylbis(imino-3,1-(4-methyl-phenylene)carbonylimino))bis(naphthalene-2,6-disulfonic acid) tetrasodium salt
纯度： ≥95% (HPLC)
生物活性 for NF 340
P2Y11 antagonist; exhibits 520-fold selectivity for P2Y11 over P2Y1, P2Y2, P2Y4, P2Y6 and P2Y12 receptors. Displays competitive antagonism against ATPγS (pIC50 values are 6.43 and 7.14 in Ca2+ and cAMP assays respectively).
技术数据 for NF 340
| 分子量 | 986.84 |
| 公式 | C37H26N4Na4O15S4 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 202982-98-7 |
| PubChem ID | 73755007 |
| InChI Key | SJMHXBFWMZYDBY-UHFFFAOYSA-J |
| Smiles | [Na+].[Na+].[Na+].[Na+].CC1=CC=C(C=C1NC(=O)NC1=C(C)C=CC(=C1)C(=O)NC1=CC(=CC2=C1C=C(C=C2)S([O-])(=O)=O)S([O-])(=O)=O)C(=O)NC1=CC(=CC2=C1C=C(C=C2)S([O-])(=O)=O)S([O-])(=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NF 340
参考文献 for NF 340
参考文献是支持产品生物活性的出版物。
Meis et al (2010) NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-γ,γ'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleuk J.Pharmacol.Exp.Ther. 332 238 PMID: 19815812
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关键词: NF 340, NF 340 supplier, P2Y11, purinoceptors, purines, receptors, antagonists, NF340, Purinergic, P2Y, Receptors, 3830, Tocris Bioscience
7 篇 NF 340 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NF 340 的部分引用包括：
Ng (2018) Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells. Cell Signal 51 59 PMID: 30076967
Ledderose et al (2016) Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis 213 456 PMID: 26150546
Dreisig et al (2018) Human P2Y11 Expression Level Affects Human P2X7 Receptor-Mediated Cell Death. Front Immunol 9 1159 PMID: 29937766
Kinoshita et al (2018) Anti-Depressant Flu Reveals its Therapeutic Effect Via Astrocytes. EBioMedicine 32 72 PMID: 29887330
Gao et al (2013) The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Autophagy 9 31 PMID: 22825617
Barragán-Iglesias et al (2014) Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells. Mol Pain 10 29 PMID: 24886406
Nishimura et al (2015) The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLoS Pathog 11 e1005184 PMID: 26430888
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.