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Submit ReviewSC 51089
说明： Selective EP1 receptor antagonist
化学名： 8-Chlorodibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide hydrochloride
纯度： ≥99% (HPLC)
生物活性 for SC 51089
SC 51089 is a selective EP1 prostanoid receptor antagonist (Ki values are 1.3, 11.2, 17.5, 61.1, > 100, > 100, > 100, >100 and > 100 μM for EP1, TP, EP3, EP2, EP4, FP and DP receptors respectively). Attenuates PGE2-induced neuronal cell death in vitro and slows tumor growth in vivo.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for SC 51089
| 分子量 | 459.33 |
| 公式 | C22H19ClN4O3.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 146033-02-5 |
| PubChem ID | 132748 |
| InChI Key | ORMHJTXDPDGKIS-UHFFFAOYSA-N |
| Smiles | ClC3=CC2=C(C=C3)OC1=CC=CC=C1CN2C(NNC(CCC4=CC=NC=C4)=O)=O.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SC 51089
参考文献 for SC 51089
参考文献是支持产品生物活性的出版物。
Abramovitz et al (2000) The utilization of recombinant prostanoid receptors determine the affinities and selectivities of prostaglandins and related analogs. Biochim.Biophys.Acta 1483 285 PMID: 10634944
Saleem et al (2007) Effect of EP1 receptor on cerebral blood flow in the middle cerebral artery occlusion model of stroke in mice. J.Neurosci.Res. 85 2433 PMID: 17600836
Matsuo et al (2004) Inhibition of human glioma cell growth by a PHS-2 inhibitor, NS398, and a prostaglandin E receptor subtype EP1-selective antagonist. J.Neurochem. 66 285 PMID: 15015658
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关键词: SC 51089, SC 51089 supplier, SC51089, selective, EP1, receptors, antagonists, prostanoids, PGE2, prostaglandins, prostacyclins, eicosanoids, Pfizer, Prostanoid, Receptors, 3758, Tocris Bioscience
1 篇 SC 51089 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SC 51089 的部分引用包括：
Sarah E et al (2021) Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS-1 (832/3) cell glucose-stimulated insulin secretion. Pharmacol Res Perspect 9 e00736 PMID: 33694300
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