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Submit ReviewLatrunculin A
Description: Inhibitor of actin assembly and polymerization
Chemical Name: 4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone
Purity: ≥95% (HPLC)
Biological Activity for Latrunculin A
Latrunculin A is a reversible inhibitor of actin assembly; blocks actin adenine nucleotide exchange. Complexes with actin in vitro and interacts with actin monomers only, unlike cytochalasins. Prevents actin repolymerization into filaments and disrupts the actin cytoskeleton.
This product is typically reconstituted in DMSO as a primary solvent.
Technical Data for Latrunculin A
| M. Wt | 421.55 |
| Formula | C22H31NO5S |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 76343-93-6 |
| PubChem ID | 445420 |
| InChI Key | DDVBPZROPPMBLW-IZGXTMSKSA-N |
| Smiles | C[C@@H](CC[C@]2([H])C[C@@](C[C@](O)([C@]3([H])CSC(N3)=O)O2)([H])O1)\C=C/C=C/CC/C(C)=C\C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Latrunculin A
References for Latrunculin A
References are publications that support the biological activity of the product.
Yarmola et al (2000) Actin-latrunculin A structure and function. J.Biol.Chem. 275 28120 PMID: 10859320
Morton et al (2000) Latrunculin alters the actin-monomer subunit interface to prevent polymerization. Nat.Cell Biol. 2 376 PMID: 10854330
Blasberger et al (1989) On the chemistry of latrunculins A and B. Liebigs.Ann.Chem. 1989 1171
If you know of a relevant reference for Latrunculin A, please let us know.
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Keywords: Latrunculin A, Latrunculin A supplier, inhibits, inhibitors, actin, assembly, polymerization, polymerisation, LatrunculinA, Actin, 3973, Tocris Bioscience
32 Citations for Latrunculin A
Citations are publications that use Tocris products. Selected citations for Latrunculin A include:
Zheng et al (2019) A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport. Cell Rep 28 3224-3237.e5 PMID: 31533043
Neumann et al (2018) Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation. Dev Cell 45 67 PMID: 29634937
Hsueh-Cheng et al (2018) Visualization of Membrane Pore in Live Cells Reveals a Dynamic-Pore Theory Governing Fusion and Endocytosis. Cell 173 934-945.e12 PMID: 29606354
Han et al (2016) Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation Nature 539 570 PMID: 27820945
Daniel et al (2014) Recycling endosomes undergo rapid closure of a fusion pore on exocytosis in neuronal dendrites. J Neurosci 34 11106-18 PMID: 25122907
Sandrine B et al (2022) A novel Fiji/ImageJ plugin for the rapid analysis of blebbing cells. PLoS One 17 e0267740 PMID: 35486637
Andrew G et al (2022) Cortical softening elicits zygotic contractility during mouse preimplantation development. PLoS Biol 20 e3001593 PMID: 35324889
Haag et al (2018) The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea. Cell Rep 24 2418 PMID: 30157434
Lettau et al (2018) Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells. Int Immunol 30 215 PMID: 29373679
Petrosyan et al (2016) The role of Rab6a and phosphorylation of non-muscle myosin IIA tailpiece in alcohol-induced Golgi disorganization. Sci Rep 6 31962 PMID: 27535804
Oenema et al (2016) Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices. Oncotarget 8 e65580 PMID: 23840342
Saba et al (2014) Rhinovirus-induced macrophage cytokine expression does not require endocytosis or replication. Am J Respir Cell Mol Biol 50 974 PMID: 24783958
Dalton and Carroll (2013) Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte. J Cell Sci 126 2955 PMID: 23659999
Jacob et al (2023) Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters. EMBO J 42 e112030 PMID: 36594262
Santiago et al (2020) Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells. Cancers (Basel) 12 PMID: 33003486
Yin et al (2020) Regulation of Collective Metastasis by Nanolumenal Signaling. Cell 183 395-410.e19 PMID: 33007268
Se-Young et al (2020) Dynamic Changes in the Bridging Collaterals of the Basal Ganglia Circuitry Control Stress-Related Behaviors in Mice. Mol Cells 43 360-372 PMID: 31940718
Tazerart et al (2020) A spike-timing-dependent plasticity rule for dendritic spines. Nat Commun 11 4276 PMID: 32848151
Davies et al (2018) Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity. Elife 7 PMID: 30028292
Wisdom et al (2018) Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments. Nat Commun 9 4144 PMID: 30297715
Hubaud et al (2017) Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock. Cell 171 668 PMID: 28942924
Suzuki et al (2015) Spatiotemporal quantification of subcellular ATP levels in a single HeLa cell during changes in morphology. Neuron 5 16874 PMID: 26575097
Araki et al (2015) Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP. PLoS One 85 173 PMID: 25569349
Richard A et al (2021) Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles. Neuron 109 938-946.e5 PMID: 33508244
Maria F et al (2021) ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells. Elife 10 PMID: 34169836
Artur et al (2021) Axon terminals control endolysosome diffusion to support synaptic remodelling. Life Sci Alliance 4 PMID: 34226200
Lionarons et al (2019) RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance. Cancer Cell 36 68 PMID: 31257073
Arash et al (2014) Arhgef7 promotes activation of the Hippo pathway core kinase Lats. EMBO J 33 2997 PMID: 25425573
Kawashima et al (2012) Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology. Chem Biol 19 893 PMID: 22840777
Lim et al (2019) Identification of the kinase STK25 as an upstream activator of LATS signaling. Nat Commun 10 1547 PMID: 30948712
Koopmans et al (2016) Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction. Sci Rep 6 30676 PMID: 27468699
Zhen et al (2009) Dopamine D4 receptors regulate AMPA receptor trafficking and glutamatergic transmission in GABAergic interneurons of prefrontal cortex. J Neurosci 29 550-62 PMID: 19144855
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