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Description: Selective glutamate carboxypeptidase II (GCP II) inhibitor; orally bioavailable
Chemical Name: 2-(3-Mercaptopropyl)pentanedioic acid
Biological Activity for 2-MPPA
2-MPPA is a selective glutamate carboxypeptidase II (GCP II) inhibitor (IC50 = 90 nM). Selective for GCP II over NMDA, kainate and AMPA glutamate receptors and MMP-1, -2, -3, -7, -9, ACE and NEP metalloproteases. Antinociceptive in a rat model of neuropathic pain and protects against motor neuron death in familial amyotrophic lateral sclerosis mice. Orally bioavailable.
Technical Data for 2-MPPA
| M. Wt | 206.26 |
| Formula | C8H14O4S |
| Storage | Store at -20°C |
| CAS Number | 254737-29-6 |
| PubChem ID | 10198171 |
| InChI Key | FNLNSQHJKVQCBP-UHFFFAOYSA-N |
| Smiles | SCCCC(C(O)=O)CCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 2-MPPA
References for 2-MPPA
References are publications that support the biological activity of the product.
Majer et al (2003) Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J.Med.Chem. 46 1989 PMID: 12723961
Ghadge et al (2003) Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models. Proc.Natl.Acad.Sci.U.S.A. 100 9554 PMID: 12876198
Vornov et al (2013) Pharmacokinetics and pharmacodynamics of the glutamate carboxypeptidase II inhibitor 2-MPPA show prolonged alleviation of neuropathic pain through an indirect mechanism. J.Pharmacol.Exp.Ther. 346 406 PMID: 23776202
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Keywords: 2-MPPA, 2-MPPA supplier, selective, glutamate, carboxypeptidase, 2, II, GCP2, GCPII, inhibitors, inhibits, neuroprotective, antinociceptive, orally, bioavailable, Carboxypeptidase, Miscellaneous, Glutamate, 5033, Tocris Bioscience
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