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Submit ReviewSC 51089
Description: Selective EP1 receptor antagonist
Chemical Name: 8-Chlorodibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for SC 51089
SC 51089 is a selective EP1 prostanoid receptor antagonist (Ki values are 1.3, 11.2, 17.5, 61.1, > 100, > 100, > 100, >100 and > 100 μM for EP1, TP, EP3, EP2, EP4, FP and DP receptors respectively). Attenuates PGE2-induced neuronal cell death in vitro and slows tumor growth in vivo.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for SC 51089
| M. Wt | 459.33 |
| Formula | C22H19ClN4O3.HCl |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 146033-02-5 |
| PubChem ID | 132748 |
| InChI Key | ORMHJTXDPDGKIS-UHFFFAOYSA-N |
| Smiles | ClC3=CC2=C(C=C3)OC1=CC=CC=C1CN2C(NNC(CCC4=CC=NC=C4)=O)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SC 51089
References for SC 51089
References are publications that support the biological activity of the product.
Abramovitz et al (2000) The utilization of recombinant prostanoid receptors determine the affinities and selectivities of prostaglandins and related analogs. Biochim.Biophys.Acta 1483 285 PMID: 10634944
Saleem et al (2007) Effect of EP1 receptor on cerebral blood flow in the middle cerebral artery occlusion model of stroke in mice. J.Neurosci.Res. 85 2433 PMID: 17600836
Matsuo et al (2004) Inhibition of human glioma cell growth by a PHS-2 inhibitor, NS398, and a prostaglandin E receptor subtype EP1-selective antagonist. J.Neurochem. 66 285 PMID: 15015658
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Keywords: SC 51089, SC 51089 supplier, SC51089, selective, EP1, receptors, antagonists, prostanoids, PGE2, prostaglandins, prostacyclins, eicosanoids, Pfizer, Prostanoid, Receptors, 3758, Tocris Bioscience
1 Citation for SC 51089
Citations are publications that use Tocris products. Selected citations for SC 51089 include:
Sarah E et al (2021) Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS-1 (832/3) cell glucose-stimulated insulin secretion. Pharmacol Res Perspect 9 e00736 PMID: 33694300
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