Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review1-Methyl-D-tryptophan
说明： Indoleamine 2,3-dioxygenase (IDO) inhibitor
别名： 1MT
纯度： ≥97% (HPLC)
生物活性 for 1-Methyl-D-tryptophan
1-Methyl-D-tryptophan is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 = 7 μM); disrupts tryptophan catabolism. Enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. Reduces tumor volume in mice with xenografts overexpressing IDO.
技术数据 for 1-Methyl-D-tryptophan
| 分子量 | 218.25 |
| 公式 | C12H14N2O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 110117-83-4 |
| PubChem ID | 405012 |
| InChI Key | ZADWXFSZEAPBJS-SNVBAGLBSA-N |
| Smiles | CN1C=C(C[C@H](C(O)=O)N)C2=CC=CC=C21 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for 1-Methyl-D-tryptophan
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 1.09 | 5 温和加热 |
制备储备液 for 1-Methyl-D-tryptophan
以下数据基于产品分子量 218.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 91.64 mL | 458.19 mL | 916.38 mL |
| 0.25 mM | 18.33 mL | 91.64 mL | 183.28 mL |
| 0.5 mM | 9.16 mL | 45.82 mL | 91.64 mL |
| 2.5 mM | 1.83 mL | 9.16 mL | 18.33 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for 1-Methyl-D-tryptophan
参考文献 for 1-Methyl-D-tryptophan
参考文献是支持产品生物活性的出版物。
Nakamura et al (2015) Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice. Int.J.Hematol. 102 327 PMID: 26243621
Rytelewski et al (2014) Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. PLoS One 9 e90439 PMID: 24587363
If you know of a relevant reference for 1-Methyl-D-tryptophan, please let us know.
按产品操作查看相关产品
关键词: 1-Methyl-D-tryptophan, 1-Methyl-D-tryptophan supplier, 1, MT, Indoleamine, 2,3-dioxygenase, IDO, inhibitors, inhibits, cancer, immunology, 1MT, 2,3, dioxygenase, Immune, Checkpoints, 5698, Tocris Bioscience
1 篇 1-Methyl-D-tryptophan 的引用文献
引用文献是使用了 Tocris 产品的出版物。 1-Methyl-D-tryptophan 的部分引用包括：
Howard L et al (2019) Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci 22 729-740 PMID: 30962630
您是否知道使用了 Tocris 1-Methyl-D-tryptophan 的优秀论文？ 请告知我们.
1-Methyl-D-tryptophan 的评论
目前没有该产品的评论。 Be the first to review 1-Methyl-D-tryptophan and earn rewards!
Have you used 1-Methyl-D-tryptophan?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.
Cancer Metabolism Poster
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.