10-Cl-BBQ

Cat. No. 6321 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent aryl hydrocarbon receptor (AhR) agonist; orally bioavailable

化学名： 10-Chloro-7H-benzimidazo[2,1-a]benz[de]isoquinolin-7-one

纯度： ≥97% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 10-Cl-BBQ

10-Cl-BBQ is a potent aryl hydrocarbon receptor (AhR) agonist, discovered as a screening hit (IC₅₀ = 2.6 nM). Directly binds CD4⁺ T cells to induce AhR-dependent Tregs. Suppresses IL-17 production and prevents insulitis in NOD mice. In vivo half llife ~ 2 hours, orally bioavailable.

技术数据 for 10-Cl-BBQ

分子量	304.73
公式	C₁₈H₉ClN₂O
储存	Store at +4°C
纯度	≥97% (HPLC)
CAS Number	23982-76-5
PubChem ID	1778614
InChI Key	ZJESJVGSDQOZAT-UHFFFAOYSA-N
Smiles	ClC1=CC2=C(N=C3N2C(C4=CC=CC5=C4C3=CC=C5)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 10-Cl-BBQ

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	0.3	1 温和加热

制备储备液 for 10-Cl-BBQ

以下数据基于产品分子量 304.73。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.01 mM	328.16 mL	1640.8 mL	3281.59 mL
0.05 mM	65.63 mL	328.16 mL	656.32 mL
0.1 mM	32.82 mL	164.08 mL	328.16 mL
0.5 mM	6.56 mL	32.82 mL	65.63 mL

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产品说明书 for 10-Cl-BBQ

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 10-Cl-BBQ

参考文献是支持产品生物活性的出版物。

Punj et al (2014) Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. PLoS One 9 e88726 PMID: 24586378

Ehrlich et al (2016) Activation of the aryl hydrocarbon receptor by 10-Cl-BBQ prevents insulitis and effector T cell development independently of Foxp3+ regulatory T Cells in nonobese diabetic mice. J.Immunol. 196 264 PMID: 26573835

If you know of a relevant reference for 10-Cl-BBQ, please let us know.

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关键词: 10-Cl-BBQ, 10-Cl-BBQ supplier, Potent, aryl, hydrocarbon, receptor, AhR, agonists, antagonism, Tregs, insulitis, orally, bioavailable, Aryl, Hydrocarbon, Receptors, 6321, Tocris Bioscience

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