¹⁰Panx

Cat. No. 3348 8 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions

纯度： ≥95% (HPLC)

引用文献 (8)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ¹⁰Panx

¹⁰Panx is a panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X₇-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. Also blocks activation of NMDA receptor secondary currents (I_2nd) by > 70%.

技术数据 for ¹⁰Panx

分子量	1242.37
公式	C₅₈H₇₉N₁₅O₁₆
序列	WRQAAFVDSY
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	955091-53-9
PubChem ID	44233736
InChI Key	JCJASTVQGSKHKZ-QZHJRRRASA-N
Smiles	[H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ¹⁰Panx

溶解性	Soluble to 1 mg/ml in water

产品说明书 for ¹⁰Panx

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ¹⁰Panx

参考文献是支持产品生物活性的出版物。

Pelegrin and Surprenant (2006) Pannexin-1 mediates large pore formation and interleukin-1β; release by the ATP-gated P2X₇ receptor. EMBO J. 25 5071 PMID: 17036048

Wang et al (2007) Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am.J.Physiol.Cell Physiol. 293 C1112 PMID: 17652431

Thompson et al (2008) Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science 322 1555 PMID: 19056988

If you know of a relevant reference for ¹⁰Panx, please let us know.

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关键词: 10Panx, 10Panx supplier, Panx-1, mimetic, inhibitory, peptide, blocks, pannexin-1, gap, junctions, Connexins, Channels, modulators, Gap, 3348, Tocris Bioscience