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说明： Antagonist of neurosteroid potentiation and direct gating of GABAA
化学名： 17-Phenyl-(3α,5α)-androst-16-en-3-ol
纯度： ≥99% (HPLC)
生物活性 for 17-PA
17-PA is a selective antagonist of neurosteroid potentiation and direct gating of GABAA receptors. Selectively reduces the effects of 5α-reduced steroids compared to 5β-reduced steroids and displays no effect on potentiation evoked by barbiturates and benzodiazepines. Attenuates 3α,5α-THP-induced loss of righting reflex and total sleep time following i.c.v administration in rats.
技术数据 for 17-PA
| 分子量 | 350.54 |
| 公式 | C25H34O |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 694438-95-4 |
| PubChem ID | 25068278 |
| InChI Key | SINAMTXBCYKFDL-WBJZGETLSA-N |
| Smiles | O[C@@H]1CC[C@@]2(C)[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC=C4C5=CC=CC=C5)([H])C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for 17-PA
参考文献 for 17-PA
参考文献是支持产品生物活性的出版物。
Mennerick et al (2004) Selective antagonism of 5α-reduced neurosteroid effects at GABAA receptors. Mol.Pharmacol. 65 1191 PMID: 15102947
Akk et al (2007) Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the α1β2γ2L GABAA receptor. Mol.Pharmacol. 71 461 PMID: 17105870
Kelley et al (2007) Antagonism of neurosteroid modulaton of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol. Eur.J.Pharmacol. 572 94 PMID: 17658511
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关键词: 17-PA, 17-PA supplier, antagonists, neurosteroid, potentiation, direct, gating, GABAA, Receptors, 2681, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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