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193 D7

Cat. No. 8167 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： JMJD1C inhibitor
化学名： 8-Benzoyl-2,3,6,7-tetrahydro-5-oxo-5H-thiazolo[3,2-a]pyridine-6-acetic acid
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 193 D7

193 D7 is a histone demethylase JMJD1C inhibitor (IC50 = 0.59 μM in in vitro demethylation assay). In vivo, 193 D7 suppresses tumor by targeting intratumoral Treg cells in mice tumor models. 193 D7 is orally bioavailable.

技术数据 for 193 D7

分子量 317.36
公式 C16H15NO4S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 861224-48-8
PubChem ID 12182298
InChI Key DZLRINQZFUBGSQ-UHFFFAOYSA-N
Smiles O=C(CC1C(N2C(SCC2)=C(C1)C(C3=CC=CC=C3)=O)=O)O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 193 D7

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 31.74 100
ethanol 6.35 20

制备储备液 for 193 D7

以下数据基于产品分子量 317.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.75 mL 31.51 mL
5 mM 0.63 mL 3.15 mL 6.3 mL
10 mM 0.32 mL 1.58 mL 3.15 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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参考文献 for 193 D7

参考文献是支持产品生物活性的出版物。

Long et al (2024) Targeting JMJD1C to selectively disrupt tumor Treg cell fitness enhances antitumor immunity. Nat.Immunol. 25 525 PMID: 38356061

If you know of a relevant reference for 193 D7, please let us know.

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关键词: 193 D7, 193 D7 supplier, 193D7, histone, demethylases, inhibits, inhibitors, JMJD1C, KDM3C, selective, antiproliferative, orally, bioavailable, in, vivo, Histone, Demethylases, 8167, Tocris Bioscience

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