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Submit Review(1S,3R)-ACPD
Discontinued Product
0284 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
说明： Group I and group II mGlu agonist; active isomer of (±)-trans-ACPD (Cat. No. 0187)
化学名： (1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid
纯度： ≥98% (HPLC)
生物活性 for (1S,3R)-ACPD
(1S,3R)-ACPD is an active isomer of (±)-trans-ACPD. Agonist at both group I and II mGlu receptors (EC50 values are 5, 15, 42 and 60 μM at mGluR2, mGluR5, mGluR1 and mGluR6 respectively).
NPEC-caged-(1S,3R)-ACPD, (±)-trans-ACPD and cis-ACPD also available.
技术数据 for (1S,3R)-ACPD
| 分子量 | 173.17 |
| 公式 | C7H11NO4 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 111900-32-4 |
| PubChem ID | 104766 |
| InChI Key | YFYNOWXBIBKGHB-FBCQKBJTSA-N |
| Smiles | N[C@]1([C@@](O)=O)C[C@]([H])([C@](O)=O)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for (1S,3R)-ACPD
参考文献 for (1S,3R)-ACPD
参考文献是支持产品生物活性的出版物。
Conti et al (2002) Synthesis and pharmacology of 3-hydroxy-Δ2-isoxazoline-cyclopentance analogues of glutamic acid. Farmaco 57 889 PMID: 12484537
Knopfel et al (1995) Metabotropic glutamate receptors: novel targets for drug development. J.Med.Chem. 38 1417 PMID: 7738999
Mistry and Challis (1996) Differences in agonist and antagonist activities for two indicies of metabotropic glutamate receptor-stimulated phosphoinositide turnover. Br.J.Pharmacol. 117 1735 PMID: 8732284
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关键词: (1S,3R)-ACPD, (1S,3R)-ACPD supplier, Group, II, group, I, mGlur, agonists, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, mGlu1, mGlu5, mGluR1, mGluR5, (Metabotropic), 0284, Tocris Bioscience
6 篇 (1S,3R)-ACPD 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (1S,3R)-ACPD 的部分引用包括：
Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236
Andlauer et al (2014) Drep-2 is a novel synaptic protein important for learning and memory. J Neurosci 3 PMID: 25392983
Blanco et al (2008) Tone-dependent vascular responses to astrocyte-derived signals. Am J Physiol Heart Circ Physiol 294 H2855 PMID: 18456724
Pasquale and Sherman (2013) A modulatory effect of the feedback from higher visual areas to V1 in the mouse. J Neurophysiol 109 2618 PMID: 23446698
Tang et al (2015) Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP. J Neurosci 35 3016 PMID: 25698739
Yamada et al (2008) Long-range axonal calcium sweep induces axon retraction. Sci Adv 28 4613 PMID: 18448637
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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