1S,3R-RSL3

Cat. No. 6118 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Inhibits glutathione peroxidase (GPX4); induces ferroptosis

化学名： (1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate

纯度： ≥98% (HPLC)

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 1S,3R-RSL3

1S,3R-RSL3 is a glutathione peroxidase 4 (GPX4) inhibitor. Induces ferroptosis. Increases lipid peroxidase levels in vitro. Inhibits tumor formation and progression in vivo.

Negative control 1R,3R-RSL3 (Cat. No. 6687) also available.

许可信息

Sold with the permission of Columbia University.

技术数据 for 1S,3R-RSL3

分子量	440.88
公式	C₂₃H₂₁ClN₂O₅
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1219810-16-8
PubChem ID	16398939
InChI Key	TXJZRSRTYPUYRW-YMXDCFFPSA-N
Smiles	COC([C@H]1CC2=C([C@H](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=CC=CC=C24)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 1S,3R-RSL3

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	44.09	100

制备储备液 for 1S,3R-RSL3

以下数据基于产品分子量 440.88。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.27 mL	11.34 mL	22.68 mL
5 mM	0.45 mL	2.27 mL	4.54 mL
10 mM	0.23 mL	1.13 mL	2.27 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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产品说明书 for 1S,3R-RSL3

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 1S,3R-RSL3

参考文献是支持产品生物活性的出版物。

Yang et al (2014) Regulation of ferroptotic cancer cell death by GPX4. Cell. 156 317 PMID: 24439385

Yang et al (2016) Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc.Natl.Acad.Sci.U.S.A. 113 E4966 PMID: 27506793

Feng & Stockwell et al (2018) Unsolved mysteries: How does lipid peroxidation cause ferroptosis? PLoS. Biol. 16 e2006203 PMID: 29795546

If you know of a relevant reference for 1S,3R-RSL3, please let us know.

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关键词: 1S,3R-RSL3, 1S,3R-RSL3 supplier, Ferroptosis, activator, activates, glutathione, peroxidase, 4, GPX4, inhibitors, inhibits, Other, Reductase, 6118, Tocris Bioscience