2',3'-cGAMP sodium salt

Cat. No. 5945 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Endogenous high affinity STING agonist

化学名： 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 2',3'-cGAMP sodium salt

2',3'-cGAMP sodium salt is a endogenous high affinity STING agonist (K_d values are 3.79 and 120 nM for human and rat STING, respectively). Induces repolarization of M2 macrophages in vitro.

This product is sold in units of 359μg, equivalent to 0.5μmol.

技术数据 for 2',3'-cGAMP sodium salt

分子量	718.37
公式	C₂₀H₂₂N₁₀Na₂O₁₃P₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2734858-36-5
PubChem ID	71563406
InChI Key	XRILCFTWUCUKJR-INFSMZHSSA-N
Smiles	[H][C@]12COP(O[C@]3([C@H]([C@H](N4C=NC5=C(N=CN=C45)N)O[C@@]3(COP(O[C@@]([C@H](N6C=NC7=C6N=C(NC7=O)N)O1)([C@@H]2O)[H])(O[Na])=O)[H])O)[H])(O[Na])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 2',3'-cGAMP sodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	35.92	50

制备储备液 for 2',3'-cGAMP sodium salt

以下数据基于产品分子量 718.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	2.78 mL	13.92 mL	27.84 mL
2.5 mM	0.56 mL	2.78 mL	5.57 mL
5 mM	0.28 mL	1.39 mL	2.78 mL
25 mM	0.06 mL	0.28 mL	0.56 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for 2',3'-cGAMP sodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 2',3'-cGAMP sodium salt

参考文献是支持产品生物活性的出版物。

Zhang et al (2013) Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol.Cell. 51 226 PMID: 23747010

Downey et al (2014) DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization. PLoS One 9 e99988 PMID: 24940883

Zhang et al (2015) Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci.Rep. 5 18035 PMID: 26669264

If you know of a relevant reference for 2',3'-cGAMP sodium salt, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 STING-Dependent Signaling Agonists

关键词: 2',3'-cGAMP sodium salt, 2',3'-cGAMP sodium salt supplier, endogenous, high, affinity, STING, agonists, STING-Dependent, Signaling, 5945, Tocris Bioscience

篇 2',3'-cGAMP sodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 2',3'-cGAMP sodium salt 的引用文献。您是否知道使用了 Tocris 2',3'-cGAMP sodium salt 的优秀论文？请告知我们.