2,4-Diamino-6-hydroxypyrimidine

Name: 2,4-Diamino-6-hydroxypyrimidine
Brand: Tocris Bioscience
SKU: 0476

Cat. No. 0476 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0476 has been discontinued.

View all Other Nitric Oxide products.

说明： Inhibits tetrahydrobiopterin synthesis and thus NOS activity

纯度： ≥99% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for 2,4-Diamino-6-hydroxypyrimidine

2,4-Diamino-6-hydroxypyrimidine is a GTP cyclohydrolase I (GCH1) inhibitor. Prevents the de novo synthesis of tetrahydrobiopterin (BH4) and thus suppresses the activity of NO synthase. Exhibits more potent inhibition of GCH1 in the presence of GFRP (GTP cyclohydrolase feedback-regulatory protein).

技术数据 for 2,4-Diamino-6-hydroxypyrimidine

分子量	126.12
公式	C₄H₆N₄O
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	56-06-4
PubChem ID	2944
InChI Key	SWELIMKTDYHAOY-UHFFFAOYSA-N
Smiles	NC1=NC(N)=NC(O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for 2,4-Diamino-6-hydroxypyrimidine

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 2,4-Diamino-6-hydroxypyrimidine

参考文献是支持产品生物活性的出版物。

Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPs 18 204 PMID: 9226999

Werner-Felmayer et al (1993) Pteridine biosynthesis in human endothelial cells. Impact of NO-mediated formation of cyclic GMP. J.Biol.Chem. 268 1842 PMID: 7678411

Xie et al (1998) GTP cyclohydrolase I inhibition by the prototypic inhibitor 2,4-diamino-6-hydroxypyrimidine. J.Biol.Chem. 273 21091 PMID: 9694862

Charles et al (2019) Pharmacological inhibition of guanosine triphosphate cyclohydrolase1 elevates tyrosine phosphorylation of caveolin1 and cellular senescence. Eur.J.Pharmacol. 848 1 PMID: 30690003

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关键词: 2,4-Diamino-6-hydroxypyrimidine, 2,4-Diamino-6-hydroxypyrimidine supplier, GTP, cyclohydrolase, I, inhibitor, GCH1, GTPCH, GCH, inhibitors, inhibits, biosynthesis, tetrahydrobiopterin, BH4, NOS, Nitric, Oxide, synthase, Signaling, Signalling, Other, Hydrolases, 0476, Tocris Bioscience

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