2-BFI hydrochloride

Cat. No. 0348 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, selective I₂ ligand. Putative agonist

化学名： 2-(2-Benzofuranyl)-2-imidazoline hydrochloride

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 2-BFI hydrochloride

2-BFI hydrochloride is a high affinity I₂ ligand (K_i = 9.8 nM). Putative I₂ agonist; potentiates morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.

技术数据 for 2-BFI hydrochloride

分子量	222.67
公式	C₁₁H₁₀N₂O.HCl
储存	Desiccate at RT
CAS Number	89196-95-2
PubChem ID	45073465
InChI Key	RFNFFVDVGWOSNZ-UHFFFAOYSA-N
Smiles	Cl.C1CN=C(N1)C1=CC2=CC=CC=C2O1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 2-BFI hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water		100

制备储备液 for 2-BFI hydrochloride

以下数据基于产品分子量 222.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4.49 mL	22.45 mL	44.91 mL
5 mM	0.9 mL	4.49 mL	8.98 mL
10 mM	0.45 mL	2.25 mL	4.49 mL
50 mM	0.09 mL	0.45 mL	0.9 mL

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产品说明书 for 2-BFI hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 2-BFI hydrochloride

参考文献是支持产品生物活性的出版物。

Alemany et al (1997) Labelling of I_2B-imidazoline receptors by [³H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) in rat brain and liver: characterization, regulation and relation to monoamine oxidase enzymes. Naunyn Schmiedebergs Arch.Pharmacol. 356 39 PMID: 9228188

MacInnes and Duty (2004) Locomotor effects of imidazoline I₂-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxyDA lesion of the nigrostriatal pathway. Br.J.Pharmacol. 143 952 PMID: 15545290

Sanchez-Blasquez et al (2000) Activation of I₂-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br.J.Pharmacol. 130 146 PMID: 10781010

If you know of a relevant reference for 2-BFI hydrochloride, please let us know.

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关键词: 2-BFI hydrochloride, 2-BFI hydrochloride supplier, Potent, selective, I2, ligand, Putative, agonists, Imidazoline, Receptors, 0348, Tocris Bioscience

2 篇 2-BFI hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 2-BFI hydrochloride 的部分引用包括：

Kim et al (2011) Icilin-evoked behavioral stimulation is attenuated by alpha₂-adrenoceptor activation. Brain Res 1384 110 PMID: 21315691

McDonald et al (2020) On the formation and nature of the imidazoline I₂ binding site on human monoamine oxidase-B. Pharmacol Res 62 475 PMID: 20832472

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