25-Hydroxycholesterol

Cat. No. 5741 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Inhibits hepatitis C viral life cycle; also α-crystallin (cryAB) chaperone

化学名： Cholest-5-ene-3β,25-diol

纯度： ≥95% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 25-Hydroxycholesterol

25-Hydroxycholesterol is an antiviral. Stimulates expression of miR-185 microRNA which inhibits the hepatitis C virus life cycle via inhibition of cholesterol biosynthesis and virus cell membrane fusion. Also α-crystallin (cryAB) chaperone (K_d = 10.1 μM). Blocks α-crystallin aggregation and partially reverses cataract formation by binding and stabilizing soluble forms of cryAB in vitro and in vivo.

技术数据 for 25-Hydroxycholesterol

分子量	402.65
公式	C₂₇H₄₆O₂
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	2140-46-7
PubChem ID	65094
InChI Key	INBGSXNNRGWLJU-ZHHJOTBYSA-N
Smiles	O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C)(O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 25-Hydroxycholesterol

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	ethanol	8.05	20

制备储备液 for 25-Hydroxycholesterol

以下数据基于产品分子量 402.65。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	12.42 mL	62.09 mL	124.18 mL
1 mM	2.48 mL	12.42 mL	24.84 mL
2 mM	1.24 mL	6.21 mL	12.42 mL
10 mM	0.25 mL	1.24 mL	2.48 mL

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产品说明书 for 25-Hydroxycholesterol

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 25-Hydroxycholesterol

参考文献是支持产品生物活性的出版物。

Singaravelu et al (2015) MicroRNAs regulate the immunometabolic response to viral infection in the liver. Nat.Chem.Biol. 11 988 PMID: 26479438

Makley et al (2015) Pharmacological chaperone for alpha-crystallin partially restores transparency in cataract models. Science 350 674 PMID: 26542570

If you know of a relevant reference for 25-Hydroxycholesterol, please let us know.

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关键词: 25-Hydroxycholesterol, 25-Hydroxycholesterol supplier, Antiviral, alpha-crystallin, chaperone, a-crystallin, α-crystallin, microRNA, miR-185, hepatitis, C, virus, HCV, cholesterol, aggregation, cataract, cryAB, cryAA, amyloid, Hepatitis, Viruses, 5741, Tocris Bioscience

2 篇 25-Hydroxycholesterol 的引用文献

引用文献是使用了 Tocris 产品的出版物。 25-Hydroxycholesterol 的部分引用包括：

Keith S et al (2021) Listeria monocytogenes-infected human monocytic derived dendritic cells activate Vγ9Vδ2 T cells independently of HMBPP production. Sci Rep 11 16347 PMID: 34381163

Judith et al (2022) Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types. iScience 25 103848 PMID: 35198901

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