27-Hydroxycholesterol

Cat. No. 3907 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： LXR agonist; also ER partial agonist

别名： 27 OHC,27 HC

化学名： (3β,25R)-Cholest-5-ene-3,26-diol

纯度： ≥95% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 27-Hydroxycholesterol

27-Hydroxycholesterol is a liver X receptor (LXR) agonist. Also estrogen receptor partial agonist. Suppresses β-estradiol-mediated breast cancer cell proliferation in vitro. Also increases α-synuclein levels and induces apoptosis in human neuroblastoma cells in vitro. Endogenous cholesterol metabolite.

技术数据 for 27-Hydroxycholesterol

分子量	402.65
公式	C₂₇H₄₆O₂
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	20380-11-4
PubChem ID	123976
InChI Key	FYHRJWMENCALJY-YSQMORBQSA-N
Smiles	O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC[C@@H](C)CO

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 27-Hydroxycholesterol

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	ethanol	8.05	20

制备储备液 for 27-Hydroxycholesterol

以下数据基于产品分子量 402.65。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	12.42 mL	62.09 mL	124.18 mL
1 mM	2.48 mL	12.42 mL	24.84 mL
2 mM	1.24 mL	6.21 mL	12.42 mL
10 mM	0.25 mL	1.24 mL	2.48 mL

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产品说明书 for 27-Hydroxycholesterol

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 27-Hydroxycholesterol

参考文献是支持产品生物活性的出版物。

Rantham Prabhakara et al (2008) Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and α-synuclein in human neuroblastoma SH-SY5Y cells. J.Neurochem. 107 1722 PMID: 19014385

Fu et al (2001) 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J.Biol.Chem. 276 38378 PMID: 11504730

DuSell et al (2008) 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator Mol.Endocrinol. 22 65 PMID: 17872378

If you know of a relevant reference for 27-Hydroxycholesterol, please let us know.

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关键词: 27-Hydroxycholesterol, 27-Hydroxycholesterol supplier, 27OHC, 27HC, liver-x, receptors, agonists, estrogen, partial, SERM, selective, modulators, cholesterol, 27, OHC, HC, LXR-like, Receptors, Estrogen, and, Related, 3907, Tocris Bioscience

2 篇 27-Hydroxycholesterol 的引用文献

引用文献是使用了 Tocris 产品的出版物。 27-Hydroxycholesterol 的部分引用包括：

Gibson et al (2018) The impact of 27-hydroxycholesterol on endometrial cancer proliferation. Endocr Relat Cancer 25 381 PMID: 29371332

Schommer et al (2018) 27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons. BMC Neurosci 19 17 PMID: 29614969

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