3',2'-cGAMP sodium salt

Cat. No. 7718 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Induces expression of STING and STING-related genes; antiviral

化学名： 3',2'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 3',2'-cGAMP sodium salt

3',2'-cGAMP sodium salt is a second messenger in the antiviral immune response in Drosophila melanogaster and in bacteria. 3',2'-cGAMP is selective for Drosophila stimulator of interferon genes (dSTING); induces expression of STING and STING-related genes. After injection of drosophila C virus dsRNA into Drosophila, 3',2'-cGAMP activates STING-dependent antiviral immunity in vivo, reduces viral RNA load and increases survival. In bacteria 3',2'-cGAMP activates DNA degradation of AsCap5 and LlCap5.

技术数据 for 3',2'-cGAMP sodium salt

分子量	718.38
公式	C₂₀H₂₂N₁₀Na₂O₁₃P₂
储存	Store at -20°C
纯度	≥98% (HPLC)
InChI Key	ROQCYAKTZSZNCA-DQNSRKNCSA-L
Smiles	O[C@H]1[C@@]2([C@@]([H])(O[C@@]1(COP([O-])(O[C@@]3([C@@]([H])(COP([O-])(O2)=O)O[C@]([H])([C@@H]3O)N4C5=C(N=C4)C(N=C(N)N5)=O)[H])=O)[H])N6C7=NC=NC(N)=C7N=C6)[H].[Na+].[Na+]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 3',2'-cGAMP sodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	7.18	10

制备储备液 for 3',2'-cGAMP sodium salt

以下数据基于产品分子量 718.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	13.92 mL	69.6 mL	139.2 mL
0.5 mM	2.78 mL	13.92 mL	27.84 mL
1 mM	1.39 mL	6.96 mL	13.92 mL
5 mM	0.28 mL	1.39 mL	2.78 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for 3',2'-cGAMP sodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 3',2'-cGAMP sodium salt

参考文献是支持产品生物活性的出版物。

Slavik et al (2021) cGAS-like receptors sense RNA and control 3',2'-cGAMP signalling in Drosophila. Nature 597 109 PMID: 34261127

Fatma et al (2021) Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3',2'-cGAMP as the second messenger. Nat.Commun. 12 6831 PMID: 34737303

If you know of a relevant reference for 3',2'-cGAMP sodium salt, please let us know.

按标靶查看相关产品

关键词: 3',2'-cGAMP sodium salt, 3',2'-cGAMP sodium salt supplier, 33cgamp, sting, induces, inducer, dsting, drosophila, virus, viral, antiviral, RNA, load, immune, response, STING-Dependent, Signaling, 7718, Tocris Bioscience

篇 3',2'-cGAMP sodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 3',2'-cGAMP sodium salt 的引用文献。您是否知道使用了 Tocris 3',2'-cGAMP sodium salt 的优秀论文？请告知我们.